Journal of Blood Research & Hematologic Diseases

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Research Article, J Blood Res Hematol Dis Vol: 3 Issue: 1

Immunoglobulins And CLL- Any Association- Serum Immunoglobulin Levels And CLL-Is There A Prognostic Association

Zing NPC1, Fischer T1, Fortier SC2, Bueno da Silveira TM2 and Chiattone CS1*

1Santa Casa de Sao Paulo School of Medical Sciences, São Paulo/SP, Brazil

2Department of Hematology, Irmandade Santa Casa de Misericórdia de São Paulo, São Paulo/SP, Brazil

*Corresponding Author : Carlos Sergio Chiattone
Santa Casa de Sao Paulo School of Medical Sciences, São Paulo/SP, Brazil
Tel: + 55 11 3367 7700
E-mail: carlos.

Received: October 01, 2018 Accepted: October 29, 2018 Published: November 02, 2018

Citation: Zing NPC, Fischer T, Fortier SC, Bueno da Silveira TM, Chiattone CS (2018) Immunoglobulins and CLL: Any Association? Serum Immunoglobulin levels and CLL: Is there a Prognostic Association? J Blood Res Hematol Dis 3:1.


The level of immunoglobulins (Igs) at the time of diagnosis of chronic lymphocytic leukemia (CLL) is related to disease stage and outcomes. In order to explore this association, 161 patient records over a period of 8 years from the ISCMSP hospital were analyzed. The majority was male (52.8%), median age was 65 and classified as Binet stage A (59%). In relation to Igs, abnormal (low or high) levels were more frequently found in patients classified as Binet B/C than A (IgG: 53.32% vs. 29.21%; p=0.004; and IgA: 46.66 vs. 21.34; p=0.002, respectively). Patients with IgA deficiency had worse overall survival than those with normal values (49.6%, 5y vs. 83%, 5y; p=0.001). Abnormal IgG levels were associated with lower time to first treatment (51.7%, 5y vs. 29%, 5y; p=0.013). Therefore, immune dysfunction is associated with disease aggressiveness and poor outcomes, and Igs levels could be an important, easy to apply independent prognostic marker in CLL management, especially in the face of limited recourses.

Keywords: Chronic lymphocytic leukemia; Immunoglobulin; Hypogammaglobulinemia; Prognostic factors

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