Journal of Immunological Techniques & Infectious Diseases ISSN: 2329-9541

Research Article, J Immunol Tech Infect Dis Vol: 2 Issue: 4

In vivo Evaluation of Antimalarial and Cytotoxic Properties of Crude Aqueous Extract of the Fruiting Body of Medicinal Mushroom, Ganoderma lucidum (W.Curt.:Fr.) P. Karst in Plasmodium berghei-Infected Mice

Olarewaju M Oluba1,4*, George O Eidangbe2, Kayode E Adebisi3,4, Adewale A Odutuga1 and E Chukwu Onyeneke4
1Department of Biochemistry, College of Natural Science, Joseph Ayo Babalola University, Ikeji-Arakeji, Osun State, Nigeria
2Department of Medical Biochemistry, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria
3Department of Biochemistry, College of Pure & Applied Sciences, Kwara State University, Malete, Kwara State, Nigeria
4Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin-City, Nigeria
Corresponding author : Dr. Olarewaju M Oluba
Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin-City, Nigeria
Tel: +2347030496639
E-mail: [email protected]
Received: August 02, 2013 Accepted: October 08, 2013 Published: October 14, 2013
Citation: Oluba OM, Eidangbe GO, Adebisi KE, Odutuga AA, Onyeneke EC (2013) In Vivo Evaluation of Antimalarial and Cytotoxic Properties of Crude Aqueous Extract of the Fruiting Body of Medicinal Mushroom, Ganoderma lucidum (W.Curt.:Fr.) P. Karst in Plasmodium berghei-Infected Mice. J Immunol Tech Infect Dis 2:4. doi: 10.4172/2329-9541.1000116

Abstract

In vivo Evaluation of Antimalarial and Cytotoxic Properties of Crude Aqueous Extract of the Fruiting Body of Medicinal Mushroom, Ganoderma lucidum (W.Curt.:Fr.) P. Karst in Plasmodium berghei-Infected Mice

This study was aimed at investigating the in vivo antimalarial and cytotoxic activities of crude aqueous extracts of the fruiting bodies of Ganoderma lucidum, a mushroom with well established medicinal properties. Plasmodium berghei (1×107) was inoculated intraperitoneally into Swiss albino mice. The extract was then administered by an intra gastric tube once daily for four days starting from the day of parasite inoculation. Chloroquine (CQ) (used as standard drug), was administered through the same route.

Keywords: Malaria; Traditional medicine; Medicinal mushroom; Ganoderma lucidum; Liver function; Cytotoxicity

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