Journal of Immunological Techniques & Infectious Diseases ISSN: 2329-9541

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Review Article, J Immunol Tech Infect Dis Vol: 2 Issue: 4

Modulation of Mucosal Antiviral Immune Response at the Female Genital Tract by Immunobiotic Lactic Acid Bacteria

Maria Guadalupe Vizoso-Pinto1,2*, Julio Villena1,3,4, Virginia Rodriguez1,3, Haruki Kitazawa4, Susana Salva1,3 and Susana Alvarez1,3,5
1Immunobiotic Research Group, Argentina
2INSIBIO-CONICET, Laboratory of Infection Biology, Biomedical Department, Faculty of Medicine, National University of Tucumán, Argentina
3Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina
4Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
5Institute of Applied Biochemistry, Faculty of Biochemistry and Pharmacy, National University of Tucumán, Tucuman, Argentina
Corresponding author : Maria Guadalupe Vizoso-Pinto
Immunobiotic Research Group, INSIBIO-CONICET, Laboratory of Infection Biology, Faculty of Medicine, National University of Tucumán, Argentina
Tel: +54-9381-6497322
Fax: +54-381-4005600
E-mail: [email protected]
Received: June 14, 2013 Accepted: October 23, 2013 Published: October 28, 2013
Citation: Vizoso-Pinto MG, Villena J, Rodriguez V, Kitazawa H, Salva S, et al. (2013) Modulation of Mucosal Antiviral Immune Response at the Female Genital Tract by Immunobiotic Lactic Acid Bacteria. J Immunol Tech Infect Dis 2:4. doi: 10.4172/2329-9541.1000120

Abstract

Modulation of Mucosal Antiviral Immune Response at the Female Genital Tract by Immunobiotic Lactic Acid Bacteria

The female genital tract (FGT) has unique characteristics, which have evolved to adequately carry on its vital function of reproduction. Thus, on the one hand the FGT has to be tolerogenic enough not to reject the allogeneic sperm and fetus in order to ensure procreation and; on the other hand it should be reactive enough for clearing viral, bacterial, fungal and parasitic pathogens. To increase complexity, there is a constant exposure of mucosal cells to an endogenous microbiota, and to the direct and indirect action of sexual hormones (estradiol and progesterone). The immunity of the FGT has not been studied as extensively as the immunity of the gut, and the antiviral response at this important mucosal site is even less understood. In line with this, immune modulation by lactic acid bacteria (LAB) offers a brand new field of research.

Keywords: Female genital mucosa; TLR-ligand; Mucosal immunity; Microbiota; Immunobiotics

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