Clinical Oncology: Case Reports

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Case Report, Clin Oncol Case Rep Vol: 5 Issue: 8

Necrotizing Fasciitis Complicating Treatment Of Uterine Carcinosarcoma

Kerry J. Rodabaugh*, Rebecca Anderson

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology,University of Nebraska Medical Center, United States

*Corresponding Author: Kerry J. Rodabaugh 
Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Nebraska Medical Center 983255 Nebraska Medical Center, Omaha, NE 68198-3255, United States. E-mail:[email protected]

Received: August 03, 2022; Manuscript No: COCR-22-71090;
Editor Assigned: August 05, 2022; PreQC Id: COCR-22-71090 (PQ);
Reviewed: August 19, 2022; QC No: COCR-22-71090 (Q);
Revised: August 21, 2022; Manuscript No: COCR-22-71090 (R);
Published: August 27, 2022; DOI: 10.4172/cocr.5(8).245

Citation: Rodabaugh KJ (2022) Necrotizing Fasciitis Complicating Treatment Of Uterine Carcinosarcoma. Clin Oncol Case Rep 5:8


Background: Patients with advanced or recurrent endometrial cancer have limited options once the disease progresses following chemotherapy. The combination of checkpoint inhibitors and tyrosine kinase inhibitors has recently been approved but has the potential for significant morbidity.

Case Report: We report a case of a patient who developed necrotizing fasciitis while receiving pembrolizumab and lenvatinib as therapy for metastatic uterine carcinosarcoma. Management required four separate surgeries and prolonged hospitalization. 

Conclusion: A literature review found no previous reports of this complication with endometrial carcinomas.  The purpose of this report is to raise awareness of the possibility of necrotizing fasciitis in relation to these drugs.

Keywords: Necrotizing fasciitis; Pembrolizumab; Lenvatinib; Endometrial cancer; Uterine carcinosarcoma

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