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Journal of Womens Health, Issues and Care ISSN: 2325-9795

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Research Article, J Womens Health Issues Care Vol: 7 Issue: 3

Nesfatin-1 Differences in Cesarean Section Compared to Natural Vaginal Delivery

Najmeh Tehranian1, Matin Sadat Esmaeilzadeh2*, Shiva Pourali Roudbaneh2, Ashraf Saber Mashhad Toroqhi3, Saeideh Sadat Hajimirzaeii5, Zainab Mousavi1 and Anoshirvan Kazem Nezhad4

1Department of Midwifery, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

2Department of Midwifery, School of Nursing, Midwifery and Paramedicine, Guilan University of Medical Sciences, Rasht, Iran

3Department of Midwifery, North Khorasan University of Medical Sciences, Bojnurd, Iran

4Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

5Student Research Committee, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran

*Corresponding Author : Matin Sadat Esmaeilzadeh, M.Sc. in Midwifery Faculty member, Department of Midwifery, School of Nursing, Midwifery and Paramedicine, Guilan University of Medical Sciences, Rasht, Iran Tel: +9813-42565058 Fax: +981342565051 E-mail: [email protected]

Received: March 12, 2018 Accepted: May 16, 2018 Published: May 21, 2018

Citation: Tehranian N, Esmaeilzadeh MS, Roudbaneh SP, Toroqhi ASM, Nezhad AK, et al. (2018) Nesfatin-1 Differences in Cesarean Section Compared to Natural Vaginal Delivery. J Womens Health, Issues Care 7:3. doi: 10.4172/2325-9795.1000312

Abstract

Abstract Objective: According to previous research, delivery is known as an inflammatory process. Recently discovered Adipokine has been proved with an anti-inflammatory and anti-apoptotic role. Hence, this study aimed to investigate changes of maternal Nesfatin-1 concentrations before and after delivery. Materials and methods: In this nested case control, 166 pregnant women, aged 18-40 and meeting the inclusion criteria, were followed up during 28-32 weeks of gestational age and until after delivery. First mother’s blood serum sample was taken in the third trimester to measure nesfatin-1. Twentythree of these subjects underwent elective CS and were considered as the case group. Then, from the women with vaginal delivery, twenty-two were made homogenous concerning demographic characteristics with case group and selected as the control group. Finally, the second blood sample was taken to measure mother’s serum nesfatin-1 twenty-four hours after delivery. The blood samples were measured by ELISA kit. The data were analyzed by means of SPSS. Results: The results showed that the concentrations of Nesfatin-1 in the third trimester of pregnancy and in the first 24 hours after delivery in the C/S group were [1360.6 ± 2153.4 (Ng/L)], and [1296.8 ± 1925.5 (Ng/L)] and in the NVD group [1483.3 ± 1980.4 (Ng/L)], and [1853.8 ± 2285.7 (Ng/L)] respectively. There was an evident relationship between Nesfatin-1 concentrations before and after delivery in the NVD group (P=0.028). Also, Nesfatin-1 difference before and after delivery in the C/S group had a significant relationship with its difference in the NVD group. (P=0.025). Conclusion: It has been found that the concentrations of serum Nesfatin-1 in the NVD group significantly increased; furthermore, this hormone concentration before and after delivery in NVD were more than C/S group.

Keywords: Nesfatin-1; Pregnancy; Cesarean delivery; Natural vaginal delivery

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