A multimodal chemo-photo thermal nano platform for cancer management using doxorubicin-loaded gold nano rods

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Rida Fatima Saeed*, Uzma Azeem Awan, Abida Raza, Shaukat Ali and Nosheen Akhtar

National University of Medical Sciences (NUMS), Pakistan
National Institute of Laser and Optronics (NILOP), Pakistan
Government College University Lahore, Pakistan

: J Nanomater Mol Nanotechnol

Abstract

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The limited efficacy and significant dose-related side effects of anticancer medications are two of the constraints associated with cancer treatment. The goal of this research was to create biocompatible multifunctional drug-loaded nanoscale moieties for co-treatment (chemo-photothermal therapy) with the highest efficacy and fewest negative effects possible. The anticancer effects of doxorubicin (DOX) loaded on gold nanorods coated with the polyelectrolyte poly (sodium-4-styrenesulfonate) (PSS-GNRs) with and without NIR laser (808 nm, power density = 1.5 W/cm 2 for 2 min) irradiation are reported in this paper. With a drug loading content of 3.2 mg DOX/mL, PSS-GNRs had a drug loading capacity of about 76 percent. When compared to non-irradiated samples, cumulative DOX release increased considerably following laser exposure (p 0.05). GNRs, PSS-GNRs, and DOX-PSS-GNRs all had zeta potential values of 42 0.1 mV, 40 0.3 mV, and 39.3 0.6 mV, respectively. Biocompatibility and photothermal stability of PSS-GNRs nanocomplexes were discovered. DOX-conjugated nanocomplexes with NIR laser irradiation appear to be more effective at inhibiting cells (93%) than those without laser exposure (65%) or doxorubicin alone (84 percent). With laser irradiation, the IC 50 values of PSS-GNRs-DOX and PSS-GNRs-DOX were measured to be 7.99 and 3.12 g/mL, respectively. As a result, a combination of chemotherapy and photo thermal methods appears to be a promising platform for cancer treatment.
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Biography

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Dr. Rida Fatima Saeed, working as Assistant Professor at the Department of Biological Sciences, National University of Medical Sciences (NUMS), Rawalpindi, Pakistan since 2019. She did her BSc (Hons) (Biochemistry, 2008) and MSc (Bioscience, 2011) degrees from University of Leeds (UK). She completed my PhD (Biochemsitry/Cancer biology) in 2016, from University of Bradford, UK. Her PhD work focused on developing in vitro assays to assess the functionality and selectivity of novel small inhibitors of polysialyltransferases for use in neuroblastoma therapy. She has authored around three book chapters and different research articles.