Biomaterials with nanoscales
Jingan Li and Kun Zhang
School of Materials Science and Engineering, Zhengzhou University, China
School of Life Science, Zhengzhou University, China
: J Nanomater Mol Nanotechnol
Abstract
Cells are the smallest living units of human body's structure and function, and their behaviors should not be ignored in human physiological and pathological metabolic activities. Each cell has different scales and also presents distinct responses to specific scales: vascular endothelial cells may obtain a normal function when regulated by the 25 μm strips, but de-functions if the scale is removed; Stem cells can rapidly proliferate on the 30 nm scales nanotubes surface, while stop proliferating when the scale is changed to 100 nm. Therefore, micro and nano scales play crucial role on directing cell behaviors on biomaterials surface. Recent years, we have developed series of biomaterials surfaces with micro and/or nano scales, such as micro-patterns, nanotubes and nanoparticles to control the target cell behavior, further enhance the surface biocompatibility. This contribution will introduce part of our work and review the advances in the micro/nano scales for biomaterials surface functionalization.
The study was supported by the Joint Fund for Fostering Talents of National Natural Science Foundation of China and Henan province (U1504310), Key scientific research projects of higher education institutions in Henan province (16A430030), Key Project and Special Foundation of Research, Development and Promotion in Henan province (No. 182102310076), the Joint Fund for Fostering Talents of NCIR-MMT & HNKL-MMT (No. MMT2017-01), and Young Teachers Foundation of Zhengzhou University (No. 32210475).
Biography
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