Investigating Quiescent Cell Biology and Examining Potential Sensitization Agents for AntiCancer Treatment in the Neuronal Cell Line

Cancer is one of the most prevalent diseases affecting people across the globe. From it is the relapse of the cancer which affects maximally from the economic and social perspective. Cancer tumors are heterogeneous in nature in terms of having different cell types residing in the different phases of the cell cycle (G1/S/G2/M) as well as cells in G0 phase or quiescent phase. The cells in the cell cycle are primarily drug sensitive whereas cells in the G0 phase are drug resistant. Once the cancer treatment is stopped, transition of G0 cells to the cell cycle occurs which lead to the relapse of the cancer. The mammalian system would help identifying, designing and formulating potential sensitization agent or drugs