Ashraf Mohamed Abdellatif Author

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Influence of Aeromonas hdrophilia Infection on the Disposition Kinetic of Norfloxacin in Goldfish (Carassius auratus auratus)

Author(s):

Mohamed Aboubakr, Abdelazem Mohamed Abdelazem and Ashraf Mohamed Abdellatif

Influence of Aeromonas hdrophilia Infection on the Disposition Kinetic of Norfloxacin in Goldfish (Carassius auratus)

The pharmacokinetic of norfloxacin (10 mg kg-1) following single intravenous (IV) and oral administration (PO) in healthy goldfish were investigated. Also, repeated (PO) administration of norfloxacin in healthy and experimentally Aeromonas hydrophilia infected goldfish was studied. Following IV administration, norfloxacin obeyed a two compartments open model, distribution half-life (t1/2(α)) equal to 0.12 h, volume of distribution (Vdss) was 1.01 L kg-1, elimination halflife (t1/2(β)) was 4.30 h and total body clearance (CLtot) was 0.17 L kg-1h-1. Following PO a... view more»

DOI: 10.4172/2325-9841.1000115

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