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David H Campbell Author
Subjects of specialization
Affiliation
Anatomy, Antibody, Gene Expression , Agrin-induced Acetylcholine
Department of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona, USA
Biography
David H Campbell, Department of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona, USA. Specialized in the subject of Anatomy, Antibody, Gene Expression, Agrin-induced Acetylcholine. The research work includes Antibody to MyoD Decreases Myogenin Gene Expression and Agrin-induced Acetylcholine Receptor Clustering.
Publications
Research Article Open Access
Antibody to MyoD Decreases Myogenin Gene Expression and Agrin-induced Acetylcholine Receptor Clustering
Author(s): Erica E Anderson, David H Campbell, Kelly Ezell, Paul R Standley and Wade A Grow
Objective: A family of myogenic regulatory factors, including MyoD and myogenin, guide myogenesis and neuromuscular synapse formation. Myogenin gene expression is activated by MyoD, and one of myogenin’s functions is to activate gene expression of the acetylcholine receptor (AChR) at the neuromuscular synapse. Motor neurons release agrin as they near skeletal muscle fibers in development, which drives the clustering of existing AChRs to the site of neuromuscular synapse formation. We have previously demonstrated that continuous exposure to antibody to MyoD or myogenin decreases agrin-induced AChR clustering in C2C12 skeletal muscle cell culture. Our objective was to more specifically establish how MyoD and myogenin interact in development. Methods: C2C12 cell cultures were exposed... view more»
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