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+44 28 3718 0055Journal of Addictive Behaviors,Therapy & RehabilitationISSN: 2324-9005
Heilig M Author
Subjects of specialization
Affiliation
Alcohol; Dependence; Rhesus macaque; Intermittent access; CRH
Laboratory of Clinical and Translational Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, USA
Biography
Specialization in Food and Nutrition, Food Microbiology, Processing and Preservation, Food Engineering, Food Quality and has published article entitled “Intermittent Access To Ethanol Induces Escalated Alcohol Consumption In Primates”
Publications
Research Article Open Access
Intermittent Access To Ethanol Induces Escalated Alcohol Consumption In Primates
Author(s): Lindell SG, Schwandt ML, Suomi SJ, Rice KC, Heilig M and Barr CS
Background: Escalation of voluntary alcohol drinking is characteristic of alcohol addiction and can be induced in rodents using intermittent access to alcohol. This model has been used to evaluate candidate therapeutics, but key systems involved in the transition into alcohol addiction, such as CRF, differ in their organization between rodents and primates. We examined the ability of an intermittent access schedule to induce escalation of voluntary alcohol drinking in non-human primates and used this model to assess the role of corticotropin releasing hormone (CRF) signaling in this process.
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