Journal of Liver: Disease & TransplantationISSN: 2325-9612

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Research Article, J Liver Dis Transplant Vol: 2 Issue: 1

The Effectiveness of Venesection Therapy for Haemochromatosis Symptoms

O Niewiadomski1, A Rode1, N Bertalli2, L Gurrin2, K Allen3 and AJ Nicoll1*
1Department of Gastroenterology and Hepatology, Royal Melbourne Hospital, Melbourne, Australia
2Centre for MEGA Epidemiology, The University of Melbourne, Australia
3Murdoch Childrens Research Institute, Melbourne, Australia
Corresponding author : Amanda J Nicoll
Department of Gastroenterology and Hepatology, Royal Melbourne Hospital, PO Box RMH, VIC. 3050, Australia
Tel: 61-3-9342-7789; Fax: 61-3-9342-7848
E-mail: [email protected]
Received: January 17, 2013 Accepted: March 16, 2013 Published: March 20, 2013
Citation: Niewiadomski O, Rode A, Bertalli N, Gurrin L, Allen K, Nicoll AJ (2013) The Effectiveness of Venesection Therapy for Haemochromatosis Symptoms. J Liver: Dis Transplant 2:1. doi:10.4172/2325-9612.1000107

Abstract

The Effectiveness of Venesection Therapy for Haemochromatosis Symptoms

Hereditary haemochromatosis (HH) is an autosomal recessive disorder, characterized by iron overload, and it is the commonest genetic condition affecting people of northern European ancestry. In most HH cases (>90%), a homozygous C282Y missense mutation on the HFE gene is the causeThe aim of this study was to determine if (1) the main symptoms of haemochromatosis, fatigue and arthritis, are improved by venesection therapy, and (2) to determine the number of venesections required to reach the target ferritin level.

Keywords: Hereditary haemochromatosis; Venesection; Efficacy of therapy; Symptom resolution

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