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Journal of Sleep Disorders: Treatment and CareISSN: 2325-9639

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Research Article, J Sleep Disor Treat Care Vol: 4 Issue: 1

Effects of Melatonin on Sleep after Laparoscopic Cholecystectomy: A Randomized, Placebo-Controlled Clinical Trial

Michael T Madsen*, Jacob Rosenberg and Ismail Gögenur
Herlev Hospital, University of Copenhagen, Department of Surgery, Herlev Ringvej 75, Denmark-2730
Corresponding author : Michael Tvilling Madsen
Herlev Hospital, University of Copenhagen, Department of Surgery, Herlev Ringvej 75, DK-2730 Herlev, Denmark
Tel: +45 2785 7247; Fax: +45 38 68 36 02
E-mail: michael_ [email protected]
Received: November 17, 2014 Accepted: January 26, 2015 Published: January 28, 2015
Citation: Madsen MT, Rosenberg J, Gögenur I (2015) Effects of Melatonin on Sleep after Laparoscopic Cholecystectomy: A Randomized, Placebo-Controlled Clinical Trial. J Sleep Disor: Treat Care 4:1. doi:10.4172/2325-9639.1000152

Abstract

Effects of Melatonin on Sleep after Laparoscopic Cholecystectomy: A Randomized, Placebo-Controlled Clinical Trial

Objective: We set out to investigate whether administration of an oral dose of 5 mg melatonin in the evenings after laparoscopic cholecystectomy could reduce sleep disturbances measured by actigraphy. Methods: We performed a double-blinded, placebo-control, randomised clinical trial where 54 patients received 5 mg melatonin or placebo approximately 30 minutes before bedtime three nights postoperatively. Participants were monitored with actigraphy two nights preoperatively and three nights postoperatively. Likewise sleep, pain, general wellbeing, and fatigue were measured via visual analogue scales. Results: Melatonin administration in the postoperative period did not affect any of the objectively determined sleep parameters compared with placebo. No group difference was observed during the night time or daytime even though the overall sleep was disturbed postoperatively. Melatonin intervention did not result in improvements in the subjective parameters. Conclusions: We did not show an effect of 5 mg melatonin administration on sleep after laparoscopic cholecystectomy.

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