Journal of Sleep Disorders: Treatment and CareISSN: 2325-9639

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Case Report, J Sleep Disor Treat Care Vol: 4 Issue: 1

Improvement of Sleepiness in Connective Tissue Disorders Following H1/H2 Blockade

Daniel A Barone1*, Christina M DINapoli1, Anne Maitland2 and Ana C Krieger1
1Weill Cornell Medical College Center for Sleep Medicine, New York, NY, USA
2Comprehensive Allergy and Asthma Care, Allergy & Asthma Center in Tarrytown, NY, USA
Corresponding author : Daniel A. Barone, MD
Assistant Professor of Neurology, Weill Cornell Medical College, Center for Sleep Medicine, 425 East 61st 5th Floor, New York, NY, 10065, USA
Tel: 646-962-7378; Fax: 646-962-0455
E-mail: [email protected]
Received: July 18, 2014 Accepted: December 17, 2014 Published: December 19, 2014
Citation: Barone DA, DINapoli CM, Maitland A, Krieger AC (2015) Improvement of Sleepiness in Connective Tissue Disorders Following H1/H2 Blockade. J Sleep Disor: Treat Care 4:1. doi:10.4172/2325-9639.1000102

Abstract

Improvement of Sleepiness in Connective Tissue Disorders Following H1/H2 Blockade

This report describes two patients with connective tissue disorders, Ehlers-Danlos syndrome and systemic lupus erythematosus (SLE), presenting with excessive daytime sleepiness. It has been suggested that these conditions involve activation of mast cells, which in turn is at least partially responsible for the symptoms of sleepiness. The two patients described were treated with H1 and H2 histamine blockers, and had experienced profound improvement in their subjective symptoms. These cases will hopefully inspire further research and discussion in this area.

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