Journal of Addictive Behaviors,Therapy & RehabilitationISSN: 2324-9005

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Review Article, J Addict Behav Ther Rehabil Vol: 5 Issue: 4

A Review Of The Literature Of Mirtazapine In Co-Occurring Depression And An Alcohol Use Disorder

Cornelius JR1*, Chung TA1, Douaihy AB1, Kirisci L2, Glance J2, Kmiec J2, Wesesky MA2, FitzGerald D3 and Salloum I3
1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
2University of Pittsburgh Medical Center, Pittsburgh, USA
3University of Miami, Miami, USA
Corresponding author : Jack R. Cornelius
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O’Hara Street, PAARC Suite, Pittsburgh PA 15213, USA
Tel: 412-246-5186
E-mail: [email protected]
Received: September 28, 2016 Accepted: December 23, 2016 Published: December 30, 2016
Citation: Cornelius JR, Chung TA, Douaihy AB, Kirisci L, Glance J, et al. (2016) A Review of the Literature of Mirtazapine in Co-Occurring Depression and an Alcohol Use Disorder. J Addict Behav Ther Rehabil 5:4. doi: 10.4172/2324-9005.1000159


Background: Prior medication studies involving individuals with major depression in combination with an alcohol use disorder (MDD/AUD) have mainly focused on SSRI and tricyclic antidepressants, with generally ineffective results. Consequently, effective treatments for that common comorbid condition remain elusive. Mirtazapine is an antidepressant medicine with a unique pharmacological profile, whose effectiveness for treating noncomorbid depression reportedly may exceed that of SSRIs. Objective/Methods: We now review the published literature regarding the tolerability and efficacy of mirtazapine for the treatment of the depression and the pathological alcohol ingestion of individuals with co-occurring MDD/AUD, including a review of four of our own small studies and two studies conducted outside the United States. Results/Conclusions: The findings of these studies suggest that mirtazapine is well tolerated among persons with comorbid MDD/AUD. Results also provide some evidence of efficacy for mirtazapine for decreasing the level of depression of persons with co-occurring MDD/AUD, and suggest that decreases in depression may occur relatively quickly after starting treatment, but provide no evidence of effectiveness for decreasing the level of alcohol ingestion. Large-scale double-blind, placebo-controlled studies are warranted to further clarify the tolerability and efficacy of mirtazapine among individuals with MDD/AUD.

Keywords: Mirtazapine; Comorbid; Major depression; Alcohol use disorder

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