Journal of Neuroscience & Clinical Research

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Commentary, J Neurosci Clin Res Vol: 8 Issue: 3

Medications and Therapies for Parkinson's Disease Management

Cabell Shamim*

1Department of Neurology, University of Alabama at Birmingham, Birmingham, USA

*Corresponding Author: Cabell Shamim,
Department of Neurology, University of Alabama at Birmingham, Birmingham, USA

Received date: 28 August, 2023, Manuscript No. JNSCR-23-115245;

Editor assigned date: 30 August, 2023, PreQC No. JNSCR-23-115245 (PQ);

Reviewed date: 13 September, 2023, QC No. JNSCR-23-115245;

Revised date: 21 September, 2023, Manuscript No. JNSCR-23-115245 (R);

Published date: 29 September, 2023, DOI: 10.4172/Jnscr.1000164

Citation: Shamim C (2023) Medications and Therapies for Parkinson's Disease Management. J Neurosci Clin Res 8:3.


Parkinson's disease is a progressive neurological disorder that affects millions of people worldwide. While there is currently no cure, several medications and therapies are available to help manage its symptoms and improve the quality of life for those living with the condition.

Understanding Parkinson’s disease

Before delving into the medications and therapies, it's essential to have a basic understanding of Parkinson's disease. Parkinson's primarily affects the brain's ability to produce dopamine, a neurotransmitter responsible for regulating movement. As dopamine levels decline, individuals with Parkinson's experience a range of motor symptoms, including tremors, bradykinesia (slowness of movement), rigidity, and postural instability. Non-motor symptoms such as depression, anxiety, and sleep disturbances are also common.

Medications for Parkinson’s disease

Levodopa: Levodopa is the most commonly prescribed medication for Parkinson's disease. It is converted into dopamine in the brain, helping to alleviate motor symptoms. Levodopa is often administered in combination with another medication called carbidopa, which enhances its effectiveness and reduces side effects. Common brand names for this combination include Sinemet and Duopa.

Dopamine agonists: Dopamine agonists are medications that mimic the action of dopamine in the brain. They can be used alone or in combination with levodopa. Examples include pramipexole (Mirapex) and ropinirole (Requip).

MAO-B inhibitors: Monoamine Oxidase-B (MAO-B) inhibitors, such as rasagiline (Azilect) and selegiline (Eldepryl), help increase dopamine levels in the brain by inhibiting the enzyme that breaks it down. These medications are often used as adjuncts to levodopa.

COMT inhibitors: Catechol-O-Methyl-Transferase (COMT) inhibitors, like entacapone (Comtan) and tolcapone (Tasmar), prolong the effects of levodopa by preventing its breakdown. They are typically used in combination with levodopa/carbidopa.

Anticholinergic medications: These drugs, such as trihexyphenidyl (Artane) and benztropine (Cogentin), can help control tremors and muscle stiffness by blocking the action of acetylcholine, another neurotransmitter.

Amantadine: Amantadine is sometimes prescribed to provide relief from dyskinesias (involuntary movements) that can occur as a side effect of levodopa.

Therapies for parkinson's disease

In addition to medications, various therapies play a vital role in managing Parkinson's disease:

Physical therapy: Physical therapy can help individuals with Parkinson's disease improve their balance, flexibility, and mobility. Therapists work on strengthening muscles and addressing gait and posture issues.

Occupational therapy: Occupational therapists focus on helping patients maintain their independence in daily activities. They provide strategies to overcome difficulties with fine motor skills, such as dressing and feeding.

Speech therapy: Speech therapists assist individuals with speech and swallowing difficulties that often accompany Parkinson's disease. Techniques may include exercises to strengthen vocal cords and swallowing muscles.

Deep Brain Stimulation (DBS): Deep Brain Stimulation is a surgical procedure in which electrodes are implanted in specific regions of the brain. These electrodes are connected to a neurostimulator device implanted under the skin. DBS can significantly reduce motor symptoms, and its effects can be adjusted as needed.

Exercise and movement programs: Regular physical activity, such as dancing, yoga, and Tai Chi, can help improve balance, coordination, and overall well-being. These activities are often included in Parkinson's disease management plans.

Support groups and counseling: Living with Parkinson's disease can be emotionally challenging. Support groups and counseling provide individuals and their caregivers with a safe space to share experiences and cope with the psychological aspects of the disease.

Personalized treatment plans

It's important to note that the management of Parkinson's disease is highly individualized. The choice of medications and therapies, as well as their dosage and timing, depends on the specific needs and symptoms of each patient. A neurologist or movement disorder specialist typically leads the development of a personalized treatment plan.

Moreover, as the disease progresses, adjustments to the treatment plan may be necessary. Medication dosages may need to be modified, and new therapies may be introduced to address changing symptoms.


While there is no cure for Parkinson's disease, medications and therapies play a vital role in managing its symptoms and improving the quality of life for individuals affected by the condition. Early diagnosis and a personalized treatment plan can help individuals with Parkinson's disease lead fulfilling and active lives despite the challenges posed by the disease. Additionally, ongoing studies continues to explore new treatment options and potential breakthroughs in the understanding of this complex neurological disorder.

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