Journal of Forensic Toxicology & Pharmacology.ISSN: 2325-9841

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Research Article, J Forensic Toxicol Pharmacol Vol: 9 Issue: 2

Vitreous Humour Biochemical Parameters As Indicators for Corroborating Acute Sniper (Dichlorvos) Induced Death

Wankasi Mieebi Martins1, Agoro Eni-yimini Solomon2* and Ikimi Charles Germany2

1 Department of Medical Laboratory Science, College of Health Science, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria

2 Department of Biochemistry, Faculty of Science, Federal University Otuoke, Bayelsa State, Nigeria

*Corresponding Author : Agoro Eni-yimini Solomon
Department of Biochemistry, Faculty of Science, Federal University Otuoke, Bayelsa State, Nigeria
Tel:
08037434995
Email:
[email protected]

Received date: July 13, 2020. Accepted date: July 29, 2020, Published date: August 05, 2020

Citation: Martins WM, Solomon AE, Germany IC (2020) Vitreous Humour Biochemical Parameters As Indicators for Corroborating Acute Sniper (Dichlorvos) Induced Death. J Forensic Toxicol Pharmacol 9:2. doi: 10.37532/jftp.2020.9(2).168

Abstract

Sniper, whose active ingredient is dichlorvos, is one of the leading causes of pesticide poisoning and death. Sniper induced death is suggested to be increasing in Nigeria without a scientific basis for discriminating ante-mortem from postmortem intoxication. The study is aimed at using vitreous biochemical parameters such as proteins, lipids, electrolytes and renal function markers in corroborating sniper induced death. A total of twenty one rabbits were used for the study. The animals were divided into three groups of seven each. The control death (CD), post-mortem sniper contamination death (PSCD) and truly sniper induced death (TSID) groups. The TSID group undertook ante-mortem ingestion of 10 ml of sniper, whereas, PSCD post-mortem ingestion. The CD was sacrificed mechanically without sniper ingestion. Thereafter vitreous humour was collected. Samples were centrifuged, separated and supernatant analyzed for the studied parameters using WHO approved methods. The result showed a significant decrease (p<0.05) in vitreous chloride and glucose concentrations in both PSCD and TSID when compared to the CD. On the contrary, the vitreous proteins and sodium concentrations increased significantly (p<0.05) in the TSID when compared to the CD. In conclusion, it is suggested that the decrease in vitreous chloride concentration and increase in vitreous sodium, total protein, albumin and globulin concentrations could serve as an indicators of sniper poisoning.

Keywords: Forensic science; Vitreous humor; Dichlorvos; Lipids; Proteins; Renal Markers

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