Journal of Sleep Disorders: Treatment and CareISSN: 2325-9639

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Commentary, J Sleep Disor Treat Care Vol: 2 Issue: 3

Sodium Oxibate and Breathing

Ortega-Albás JJ1* and Ortega Gabás SP2
1Sleep Unit Universitary, General Hospital of Castellón Castellón de la Plana, Spain
2Polytechnic University of Valencia, Valencia, Spain
Corresponding author :Ortega-Albás JJ
Sleep Unit, Universitary General Hospital of Castellón, Castellón de la Plana, Avenida Capuchinos 41, 2° D. 12004. Castellón, Spain
Tel: 638713784
E-mail: [email protected]
Received: April 09, 2013 Accepted: August 08, 2013 Published: August 10, 2013
Citation: Ortega-Albás JJ, Ortega Gabás SP (2013) Sodium Oxibate and Breathing. J Sleep Disor: Treat Care 2:3. doi:10.4172/2325-9639.1000116



Sodium Oxibate and Breathing

The gamma-hydroxybutyrate acid (GHB) is a short chain fatty acid, an endogenous metabolite of gamma–aminobutyric acid (GABA), known major inhibitor neurotransmitter. The GHB presents an action fundamentally at Central Nervous System (CNS) level, and possesses a high affinity for specific receptors located in the cerebral cortex and in the medulla. Sodium Oxybate (SO) is the sodium salt of the GHB. Its character as inhibitor neuromodulator, with the possibility of inducing respiratory depression, and the potential risk of abuse/misuse forces clinicians to be constantly monitoring for signs of misuse.


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