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Journal of Forensic Toxicology and Pharmacology
Editorial Board: James T Pokines, PhD
  Boston University, USA  view all
ISSN: 2325-9841
Frequency: Biannual
 
The Journal of Forensic Toxicology and Pharmacology (JFTP) promotes rigorous research that makes a significant contribution in advancing knowledge of variations in biochemical functions and detailed information on forensic studies. The JFTP includes all major themes pertaining to forensic toxicology and pharmacology.
 
Journal of Forensic Toxicology and Pharmacology is a subscription based journal that provides a range of options to purchase our articles and also permits unlimited Internet Access to complete Journal content. It accepts research, review papers, online letters to the editors & brief comments on previously published articles or other relevant findings in SciTechnol. Articles submitted by authors are evaluated by a group of peer review experts in the field and ensures that the published articles are of high quality, reflect solid scholarship in their fields, and that the information they contain is accurate and reliable.
 
Current Issue
A Case of Fatal Ingestion of a 10% Benzalkonium Chloride Solution   Case Report
Henry A. Spiller
J Forensic Toxicol Pharmacol 2014, 3:1    doi: 10.4172/2325-9841.1000113
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A Case of Fatal Ingestion of a 10% Benzalkonium Chloride Solution

Benzalkonium chloride (BAC) is a mixture of quaternary ammonium compounds of alkyl-dimethylbenzylammonium chlorides. It has wide ranging use as a disinfectant, germicidal cleaner, algaecide, cationic detergent and topical dermal antiseptic. Ingestion of BAC can cause local caustic effects and systemic effects. The present report involved a 78 year old male with a history of severe dementia who ingested up to 240ml of a germicidal disinfectant containing 10% benzalkonium chloride. Shortly after, he complained of oral pain and nausea, and experienced one episode of vomiting. Upon arrival to the emergency department approximately 45 minutes post-ingestion the patient’s complaints included oral pain, sialorrhea, drooling, spitting, nausea, and coughing, but no increase in work of breathing. Initial evaluation of the oral cavity and oropharynx showed mild erythema and swelling, but without lesions or erosions.

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Investigation of Cholesterol Level and Body Mass Index of Completed Suicide Victims   Research Article
Şafak Taktak, Ayla Ünsal, Mustafa Karakuş and Sevil Biçer
J Forensic Toxicol Pharmacol 2014, 3:1    doi: 10.4172/2325-9841.1000114
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Investigation of Cholesterol Level and Body Mass Index of Completed Suicide Victims

The aim of this study was to investigate the cholesterol level and Body Mass Index (BMI) of completed suicide victims. Ninety cases that were consecutively referred to the Forensic Medicine Institute Morgue Department were included in the study based on evaluations of death examinations and autopsies based on psychological autopsies. Information was obtained from court documents and interviews with the suicide victims’ relatives. Blood samples of the individuals were examined within 48 hours. The data were analyzed using Mann-Whitney U tests and Pearson Correlation. Most of the victims were male (68.9%) and the most frequent suicide method was hanging (61.1%). It was determined that in 86.7% of the cases the victims had attempted suicide for the first time resulting in completed suicide.

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Influence of Aeromonas hdrophilia Infection on the Disposition Kinetic of Norfloxacin in Goldfish(Carassius auratus auratus)   Research Article
Mohamed Aboubakr, Abdelazem Mohamed Abdelazem and Ashraf Mohamed Abdellatif
J Forensic Toxicol Pharmacol 2014, 3:1    doi: 10.4172/2325-9841.1000115
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Influence of Aeromonas hdrophilia Infection on the Disposition Kinetic of Norfloxacin in Goldfish(Carassuys auratus Linnaeus)

The pharmacokinetic of norfloxacin (10 mg kg-1) following single intravenous (IV) and oral administration (PO) in healthy goldfish were investigated. Also, repeated (PO) administration of norfloxacin in healthy and experimentally Aeromonas hydrophilia infected goldfish was studied. Following IV administration, norfloxacin obeyed a two compartments open model, distribution half-life (t1/2(α)) equal to 0.12 h, volume of distribution (Vdss) was 1.01 L kg-1, elimination halflife (t1/2(β)) was 4.30 h and total body clearance (CLtot) was 0.17 L kg-1h-1. Following PO administration, norfloxacin was rapidly and efficiently absorbed through gastrointestinal tract as the absorption half-life (t1/2(ab)) was 0.84 h. Maximum serum concentration (Cmax) 4.10 μg ml-1, was achieved its maximum time (tmax) at about 2 h post administration and the elimination half-life (t1/2(el)) was 3.91 h. Oral bioavailability was 57.63% indicating moderate absorption of norfloxacin from oral site.

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Acute Intravascular Hemolysis Triggered by Herbal Remedy   Case Report
Denesh Narasimhan, Sujith Kumar S, Murali A, Satish M and Anith Kumar Mambatta
J Forensic Toxicol Pharmacol 2014, 3:1    doi: 10.4172/2325-9841.1000116
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Acute Intravascular Hemolysis Triggered by Herbal Remedy

Red blood cells (RBC) have several protective mechanisms to prevent oxidative stress. One such mechanism is the Glucose 6 phosphate dehydrogenase enzyme (G6PD). G6PD deficiency is the most common enzyme deficiency in the world. 7.5% of the world’s population have either one or two gene mutations for G6PD deficiency. Since the gene for the enzyme is located on the X chromosome in the long arm, males are generally heterozygous and women can be normal, heterozygous or homozygous.

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