Journal of Nanomaterials & Molecular NanotechnologyISSN: 2324-8777

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Research Article, J Nanomater Mol Nanotechnol Vol: 2 Issue: 7

Electrochemical Studies of Vitamin K3 and Its Interaction with Human Serum Albumin Using a Carbon Nanoparticles- Modified Electrode

H Heli1,2,3*
1Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Nanomedicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
Corresponding author : Dr. Heli H
Department of Nanomedicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
Tel/Fax: +98 711 234 93 32
E-mail: [email protected] or [email protected]
Received: September 18, 2013 Accepted: November 14, 2013 Published: November 18, 2013
Citation: Heli H (2013) Electrochemical Studies of Vitamin K3 and Its Interaction with Human Serum Albumin Using a Carbon Nanoparticles-Modified Electrode. J Nanomater Mol Nanotechnol 2:7. doi:10.4172/2324-8777.1000130

Abstract

Electrochemical Studies of Vitamin K3 and Its Interaction with Human Serum Albumin Using a Carbon Nanoparticles- Modified Electrode

The electrochemical behavior of vitamin K3 on a carbon nanoparticles-modified glassy carbon electrode surface and its interaction with human serum albumin were investigated. The results showed that vitamin K3 is reduced in a two-electron step. The diffusion coefficients of vitamin K3 was determined. Also, the heterogeneous electron transfer rate constant and charge transfer coefficient were evaluated using cyclic voltammetry, impedance spectroscopy and steady-state polarization measurements. Upon addition of human serum albumin to the vitamin K3 solution, both the cathodic and anodic peak currents were decreased; however, binding vitamin K3 to human serum albumin formed an electroreactive species. The percentage of interaction of vitamin K3 with protein was addressed.

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