Journal of Nanomaterials & Molecular NanotechnologyISSN: 2324-8777

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Research Article, J Nanomater Mol Nanotechnol Vol: 2 Issue: 2

On Further Understanding of Interaction of Pristine Carbon Nanotubes with Hemoglobin, Serum and H2S

Wu XC1,2, Eric Zhan3, Wu L4, Wu YH5 and Zhang WJ1,3*
1Complex and Intelligent System Research Laboratory (CISRL), East China University of Science and Technology, China
2Department of Comparative Biomedical Science, Louisiana State University, USA
3Department of Mechanical Engineering, University of Saskatchewan, Canada
4Department of Health Sciences, Lakehead University and Thunder Bay Regional Research Institute, Thunder Bay, ON, Canada
5Arts and Science, University of Saskatchewan, Canada
Corresponding author : Zhang WJ
Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, Canada
E-mail: [email protected]
Received: January 16, 2013 Accepted: April 17, 2013 Published: April 23, 2013
Citation: Wu XC, Zhan E, Wu L, Wu YH, Zhang WJ (2013) On Further Understanding of Interaction of Pristine Carbon Nanotubes with Hemoglobin, Serum and H2S. J Nanomater Mol Nanotechnol 2:2. doi:10.4172/2324-8777.1000110

Abstract

On Further Understanding of Interaction of Pristine Carbon Nanotubes with Hemoglobin, Serum and H2S

This paper presents a study on the interaction between H2S, pristine carbon nanotube (pCNT), and hemoglobin in the serum solution. A short-term purpose of the study is to develop a CNTbased sensor to simultaneously measure H2S and specific proteins such as hemoglobin in blood. The basic idea of the experiment is to prepare the serum-based solution that contains H2S and hemoglobin, and treat pCNT with the solution. The fluorescence response of the treated pCNT is acquired with confocal laser scanning microscopy (excitation wavelength: 514 nm; emission wavelength: 530-580 nm). The major finding of the study is that the presence of hemoglobin in a H2S and protein solution, such as the serum does not affect the fluorescence response to H2S on pCNT. Together with our previous work, it can be concluded that (1) both hemoglobin and H2S attach with pCNT by treating pCNT with the serum solution that contains hemoglobin and H2S, and (2) fluorescence response of H2S on the treated pCNT is not affected by presence of hemoglobin.
 

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