Journal of Nanomaterials & Molecular NanotechnologyISSN: 2324-8777

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Research Article, J Nanomater Mol Nanotechnol Vol: 2 Issue: 6

In Vivo Biocompatibility Evaluation of Gelatin�Hydroxyapatite Crosslink Biomimetic Scaffolds for Bone Regeneration

Sorasun Rungsiyanont1*, Kanako Noritake2, Warunee Pluemsakunthai2, Somchai Yodsanga3, Somporn Swasdison3 and Shohei Kasugai2
1Associate professor, Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Srinakharinwirot University, Thailand
2Department of Implantology,Graduation School of Tokyo Medical and Dental University, Tokyo, Japan
3Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, Pathumwan 10330, Thailand
Corresponding author : Dr. Sorasun Rungsiyanont
Associate professor, Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Srinakharinwirot University, Wattana, Bangkok 10110, Thailand
Tel/Fax: 662-6641882
E-mail: [email protected]
Received: August 15, 2013 Accepted: October 16, 2013 Published: October 20, 2013
Citation: Rungsiyanont S, Noritake K, Pluemsakunthai W, Yodsanga S, Swasdison S, et al. (2013) In Vivo Biocompatibility Evaluation of Gelatin–Hydroxyapatite Crosslink Biomimetic Scaffolds for Bone Regeneration. J Nanomater Mol Nanotechnol 2:6. doi:10.4172/2324-8777.1000126

Abstract

In Vivo Biocompatibility Evaluation of Gelatin–Hydroxyapatite Crosslink Biomimetic Scaffolds for Bone Regeneration

Biomimetic gelatin (gel)/hydroxyapatite (HA) scaffolds have been prepared for bone regeneration and hard tissue engineering. (A) 2.5% gel solely and (B) coprecipitation of 2.5% gel with 2.5% HA (w/w) were prepared to evaluate their biocompatibility, biodegradation and defect shape maintenance for regeneration. Sixteen week-old Vista rats (n=30) were used and calvarial defects were grafted with these scaffolds.

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