Journal of Nanomaterials & Molecular NanotechnologyISSN: 2324-8777

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Research Article, J Nanomater Mol Nanotechnol Vol: 2 Issue: 7

Dietary Intake of (-)-Epigallocatechin-3-gallate against Aging and Cancers: Nanoencapsulation of Multi- Rings Still Requires New Rounds!

Farid Menaa1*, Abder Menaa2, Jacques Tréton3 and Bouzid Menaa4*
1Fluorotronics, Inc., Department of Nanomedicine, Stem cells and Oncology, 2453 Cades Way, Bldg C, San Diego, CA 92081, USA
2Centre Médical des Guittières, Department of Nutrition, Dermato-Esthetics and Anti-Aging Medicine 04 rue des Guittières, Saint-Philbert de Grand Lieu 44310, France
3Université Paris V-René Descartes, UMRS INSERM U872, Department of Geriatry and Gerontology Centre de Recherches des Cordeliers, 15 rue de l'Ecole de Medicine, Paris 75006, France
4Fluorotronics, Inc., Department of Nanomaterials and Nanobiotechnology, 2453 Cades Way, Bldg C, San Diego, CA 92081, USA
Corresponding authors : Dr. Farid Menaa
Fluorotronics, Inc., Department of Nanomedicine, Stem cells and Oncology, 2453 Cades Way, Bldg C, San Diego, CA 92081, USA
Tel: +1 (858) 274.2728
E-mail: [email protected]
Dr. Bouzid Menaa
Fluorotronics, Inc., Department of Nanomaterials and Nanobiotechnology, 2453 Cades Way, Bldg C, San Diego, CA 92081, USA
Tel: +32 (4) 759-28-957
E-mail: [email protected]
Received: April 19, 2013 Accepted: November 18, 2013 Published: November 23, 2013
Citation: Menaa F, Menaa A, Tréton J, Menaa B (2013) Dietary Intake of (-)-Epigallocatechin-3-gallate against Aging and Cancers: Nanoencapsulation of Multi-Rings Still Requires New Rounds! J Nanomater Mol Nanotechnol 2:7. doi:10.4172/2324-8777.1000131

Abstract

Dietary Intake of (-)-Epigallocatechin-3-gallate against Aging and Cancers: Nanoencapsulation of Multi- Rings Still Requires New Rounds!

Polyphenols, a superfamily of naturally occurring phytochemicals, are gaining popularity because of their potential health benefits. Indeed, as demonstrated in ex-vivo and in non-primates models, they exert variable and pleiotropic biological effects (e.g. anti- or pro-oxidant, anti-inflammatory, anti-tumoral, anti-aging) depending on their structure and physicochemical features. However, these effects are often limited Carnauba wax by their overall unstability and bioavailability. The fact that some polyphenols act either as anti-oxidants (e.g. against aging) or as pro-oxidants (e.g. against tumors/cancers), remain an unsolved paradigm. Interestingly, emergent studies suggest that nano-encapsulated polyphenols might overcome some limitations frequently observed with dietary bulk-polyphenols (e.g. bioavailability, pharmacokinetics, targeting, efficacy, toxicity and safety), subsequently potentiating their biological effects. In this context, the case of (-)-epigallocatechin- 3-gallate (EGCG) is quite intriguing.

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