Research Article, J Genit Syst Disord Vol: 6 Issue: 2
Embryonic Arrest is more likely to Happen in Frozen-Thawed Embryo Transfers
Wanqiu Zhao, Mingzhao Li, Wenhao Shi and Juanzi Shi*
Department of Obstetrics & Gynecology, Faculty of Medicine and Biomedical Sciences, University Teaching Hospital, Yaoundé, Cameroon
*Corresponding Author : Juanzi Shi
The ART Center, Northwest Women’s and Children’s Hospital, Xi’an, China
E-mail: [email protected]
Received: March 22, 2017 Accepted: May 08, 2017 Published: May 16, 2017
Citation: Nkwabong E, Li M, Shi W, Shi J (2017) Embryonic Arrest is more likely to Happen in Frozen-Thawed Embryo Transfers. J Genit Syst Disord 6:2. doi: 10.4172/2325-9728.1000172
Purpose: We mainly aimed to compare the incidence of embryonic arrest between fresh embryo and frozen-thawed embryo transfers.
Methods: This study included 4592 fresh embryo and 4461 frozen-thawed embryo transfers. In fresh embryo transfers, it included 3003 cleavage-stager embryo and 1589 blastocyst-stage embryo transfers. In frozen-thawed embryo transfers, it included 1626 cleavage-stager embryo and 2835 blastocyst-stage embryo transfers. Main clinical outcomes: embryonic arrest rate.
Results: Fresh embryo transfers had a lower embryonic arrest rate than frozen-thawed embryo transfers, with statistically significant difference (6.08 versus 7.20%; p=0.032). However, in cleavagestage embryo transfers, fresh group and frozen-thawed group had no significant difference in the embryonic arrest rate (6.59 versus
6.95%; p=0.644). We also observed that the embryonic arrest rate was no significant difference between cleavage-stage embryo and blastocyst-stage embryo transfers (6.72 versus 6.53%; p=0.722). More interestingly, single cleavage-stage embryo transfers had a higher embryonic arrest rate compared with single blastocyst-stage
embryo transfers (8.13 versus 4.67%; p=0.010).
Conclusions: Embryonic development is more likely to happen in frozen-thawed embryo transfers. Frozen-thawed embryo transfers might not be a superior choice to patients with prior embryonic arrest. Extended culture to blastocyst-stage might be a superior therapy to another fresh cycle in patients with prior embryonic arrest.