Journal of Nanomaterials & Molecular NanotechnologyISSN: 2324-8777

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Research Article, J Nanomater Mol Nanotechnol Vol: 6 Issue: 4

Synthesis and Characterization of Betulinic Acid-Aminopropyltriethoxysilane Compounds and Their Assembly onto Nanoporous Alumina Surfaces as Potential Therapeutic Agents

Abdul Hadi Mahmud1, Abdul Mutalib Md Jani2* and Mohd Tajudin Mohd Ali1

1Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor, Malaysia

2Chemistry Department, Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), 02600 Arau, Perlis, Malaysia

*Corresponding Author : Abdul Mutalib Md Jani
Chemistry Department, Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), 02600 Arau, Perlis, Malaysia
Tel: +604-9882278
Fax: +604-9882484
E-mail: [email protected]

Received: May 15, 2017 Accepted: July 06, 2017 Published: July 12, 2017

Citation: Mahmud AH, Jani AMM, Ali MTM (2017) Synthesis and Characterization of Betulinic Acid-Aminopropyltriethoxysilane Compounds and Their Assembly onto Nanoporous Alumina Surfaces as Potential Therapeutic Agents. J Nanomater Mol Nanotechnol 6:4. doi: 10.4172/2324-8777.1000226

Abstract

The present study describes the synthesizing and attaching of betulinic acid-aminopropyl triethoxysilane (BA-APTES) on top of the nanoporous alumina (NA) surface. The NA was fabricated by using electrochemical anodization process under an applied voltage of 40 V for 20 hours resulting in average pore size of 45 nm characterized by Scanning Electron Microscope (SEM). The well-recognized therapeutic compound, betulinic acid (BA) was first extracted from the bark of Melaleuca cajuputi plant and further purified by column chromatography. The purified BA was incorporated with APTES using 1-hydroxybenzotriazole hydrate (HOBt) and O-(Benzotriazol-1-yl)-N,N,N’-tetramethyluronium hexafluorophosphate (HBTU) as a peptide coupling agent. The synthesized BA-APTES was silanized on top of the fabricated NA surface. The aromatic portion of 1H and 13C of the synthesized BA-APTES compound was validated by means of Nuclear Magnetic Resonance (NMR). The FTIR spectra show emerging peaks at 2900 cm-1 and 1250 cm-1 signifying the present of aldehyde and also aliphatic amine on NA, respectively. With the aid of XPS analysis, the chemical composition of BA-APTES has evidenced that the presence of the compounds on the surface of NA membrane. Hence, the authors suggest that the modified NA surface has a potential to be applied as a new material for therapeutic agent.

Keywords: Nanoporous alumina; Anodization; Porous materials; Surface modification; Silanization; Betulinic acid

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