Journal of Food and Nutritional DisordersISSN: 2324-9323

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Short Communication, J Food Nutr Disor Vol: 3 Issue: 6

Dietary Fatty Acids and Vitamin B3: An Effective Treatment Strategy for the Metabolic Syndrome?

Sergio Montserrat-de la Paz1, Sergio Lopez1, Almudena Ortega- Gomez1, Lourdes M Varela1, Rocio Abia1, Francisco JG Muriana1 and Beatriz Bermudez1,2*
1Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa (CSIC)Seville, Spain
2Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain
Corresponding author : Beatriz Bermudez
Department of Pharmacology, Faculty of Pharmacy, University of Seville , 41012 Seville, Spain
E-mail: [email protected]
Received: August 28, 2013 Accepted: October 6, 2014 Published: October 10, 2014
Citation: Montserrat-de la Paz S, Lopez S, Ortega-Gomez A, Varela LM, Abia R, et al. (2014) Dietary Fatty Acids and Vitamin B3: An Effective Treatment Strategy for the Metabolic Syndrome?. J Food Nutr Disor 3:6. doi:10.4172/2324-9323.1000157

Abstract

Dietary Fatty Acids and Vitamin B3: An Effective Treatment Strategy for the Metabolic Syndrome?

The metabolic syndrome (MS) may be defined as the constellation of cardiovascular disease (CVD) risk factors that comprises obesity, type 2 diabetes, dyslipidemia, and hypertension. Recent evidences suggest that, primarily due to its high monounsaturated fatty acids (MUFAs) content, olive oil and omega-3 polyunsaturated fatty acids (PUFAs) could be useful as a dietary approach for MS management, with relevance in the postprandial state. Vitamin B3, as a major substrate for nicotinamide phosphoribosyl transferase (NAMPT), also constitutes a nutritional intervention strategy for the treatment of MS. NAMPT has been shown to exert activities of central importance to cellular energetics and innate immunity. Within the cell, NAMPT is the rate-limiting step in a salvage pathway of nicotinamide adenine dinucleotide (NAD+) biosynthesis.

Keywords: Metabolic syndrome; Cardiovascular diseases; Dietary oleic acid; Omega-3 PUFAs; Niacin; NAMPT; NAD+

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