Journal of Genetic Disorders & Genetic Reports ISSN: 2327-5790

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Research Article, J Genet Disor Genet Rep Vol: 2 Issue: 1

Evaluation of Genomic Evidence for Oxidative Stress in Experimental Radiation Nephropathy

Eric P Cohen1*, Marek Lenarczyk3, Brian L Fish3, Shuang Jia2, Martin J Hessner2 and John E Moulder3
1Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
2Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
3Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Corresponding author : Eric P Cohen
Department of Medicine, Zablocki VAMC, 5000 W National Ave, Milwaukee, WI 53295, USA
Tel: 1-414-384-2000; Fax: 1-414-383-9333
E-mail: [email protected]
Received: October 07, 2012 Accepted: December 05, 2012 Published: December 10, 2012
Citation: Cohen EP, Lenarczyk M, Fish BL, Jia S, Hessner MJ, et al. (2013) Evaluation of Genomic Evidence for Oxidative Stress in Experimental Radiation Nephropathy. J Genet Disor Genet Rep 2:1. doi:10.4172/2327-5790.1000101

Abstract

Evaluation of Genomic Evidence for Oxidative Stress in Experimental Radiation Nephropathy

Chronic persistent oxidative stress has been proposed as a mechanism for late radiation injury to normal,tissue. Using biochemical, histological, and pharmacological techniques, we have not been able to confirm this hypothesis for late renal radiation injury. Gene expression may be more revealing,especially since the initial effects of radiation are to damage DNA.

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