Journal of Genetic Disorders & Genetic Reports ISSN: 2327-5790

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Research Article, J Genet Disor Genet Rep Vol: 2 Issue: 2

Genotype-phenotype characteristics of β thalassemia children in the Gaza Strip, Palestine

Maged M Yassin 1, Mahmoud M Sirdah2*, Rami M Al Haddad3, Abdel-Monem H. Lubbad2 and Mansour S Al-Yazji2
1Faculty of Medicine, Islamic University of Gaza, Palestine
2Biology Department, Al Azhar University-Gaza, Palestine
3Palestinian Thalassaemia and Haemophilia Centre, Palestine Avenir
Foundation, Gaza, Palestine
Corresponding author : Dr. Mahmoud Sirdah
Biology Department, Al Azhar University-Gaza, PO Box 1277, Gaza, Palestine
Tel: +97 05 99 481194; Fax: +97 082641888
E mail: [email protected]; [email protected]
Received: November 11, 2013 Accepted: December 17, 2013 Published: December 23, 2013
Citation: Yassin M M, Sirdah M M, Al Haddad R M, Lubbad A H, Al-Yazji M S (2013) Genotype-phenotype characteristics of β thalassemia children in the Gaza Strip, Palestine. J Genet Disor Genet Rep 2:2. doi:10.4172/2327-5790.1000109

Abstract

Genotype-phenotype characteristics of β thalassemia children in the Gaza Strip, Palestine

Thalassemias are considered one of the most common known hereditary blood disorders in mankind, quantitatively affecting the synthesis of human hemoglobin. At least 60,000 severely affected individuals are born every year. Thalassemias have been encountered in practically every racial group and geographic location in the world; however, they are most common among individuals originating from tropical and subtropical regions. Thalassemias are classified based on the particular globin chain(s) that are produced in a reduced amount, so the main types of this inherited disorder which have been defined are α, β, δβ, δ, γδ β, and εγδβ thalassemias.

Keywords: β-thalassemia; Children; Molecular; Biochemical and hematological parameters; Gaza strip

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