Journal of Food and Nutritional DisordersISSN: 2324-9323

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Research Article, J Food Nutr Disor Vol: 4 Issue: 3

Modelling Kinetics in Intestinal Compartment of Human Body as a Function of Applied Probiotics

Marijan Bošnjak1*, Zrinka Alfirević2, Igor Alfirević3 and Ivan Kosalec4
1Croatian Academy of Engineering, Kačićeva 28,HR-10000 Zagreb, Croatia
2Croatian Office of Pension Scheme, A. Mihanovića 3, HR-10000 Zagreb,Croatia
3Magdalena Clinical Hospital for Cardio Vascular Diseases, Faculty of Medicine, J. J. Strossmayer University in Osijek, Ljudevita Gaja, 2HR-49217 Krapinske Toplice, Croatia
4Department of Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Schrottova 39, HR-10000 Zagreb, Croatia
Corresponding author : Marijan Bošnjak
Croatian Academy of Engineering, Kaciceva 28,HR-10000 Zagreb; Home: Slovenska 19, HR-10000 Zagreb, Croatia
Tel: 385 1 3722 049
E-mail: [email protected]
Received February 11, 2015 Accepted April 09, 2015 Published April 14, 2015
Citation: Bošnjak M, Alfirevic Z, Alfirevic I, Kosalec I (2015) Modelling Kinetics in Intestinal Compartment of Human Body as a Function of Applied Probiotics. J Food Nutr Disor 4:3. doi:10.4172/2324-9323.1000173

Abstract

Modelling Kinetics in Intestinal Compartment of Human Body as a Function of Applied Probiotics

Antibiotic treatments of human body microbial infections are frequently accompanied with a series of side effects which require adequate actions. This work refers to mathematical modelling of process states in a human body appearing during infection, its treatment with antibiotics and consequent application of probiotics. A mathematical model composed of 28 differential equations is being applied to describe a) pharmacokinetics of antibiotic transfer and action, human body viability changes, probiotics transit and changes in intestinal microbiota, b) kinetics of pathogenic microbial infection and infected organism immunity development, and c) intestinal tumor growth kinetics. Computer simulation has been applied to test the adequacy of applied mathematical model. Results of computer simulations expressed graphically and in tables, confirm the model adequacy for explaining process events connected with human body infections and consequent antibiotics and probiotics treatments.

Keywords: Mathematical modelling; Computer simulation; Pharmacokinetics; Antibiotics; Microbial infection; Probiotics

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