Journal of Genetic Disorders & Genetic Reports ISSN: 2327-5790

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Research Article, J Genet Disor Genet Rep Vol: 6 Issue: 2

Expression of TCTP-Related Genes

Jun-ichi Kashiwakura1,2 and Toshiaki Kawakami1,3*

1Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA

2Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan

3Department of Dermatology, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA

*Corresponding Author : Toshiaki Kawakami, M.D, Ph.D
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA
Tel: +858-7526814
Fax: +858-7526986
E-mail: [email protected]

Received: May 06, 2017 Accepted: May 22, 2017 Published: May 30, 2017

Citation: Kashiwakura J, Kawakami T (2017) Expression of TCTP-Related Genes. J Genet Disor Genet Rep 6:2.doi: 10.4172/2327-5790.1000156

Abstract

Translationally controlled tumor protein (TCTP) encoded by TPT1 gene is a multifunctional protein involved in fundamental cellular processes of cell-cycle progression, proliferation, survival, malignant transformation, and regulation of pluripotency and cancer stem cells, as well as allergic inflammation. Here we report the cloning of four TCTP-related cDNAs from human peripheral blood mononuclear cells. These genes lack introns, suggesting that they are pseudogenes generated by retrotransposon-mediated integration of TPT1 gene. However, some of them are expressed at extremely low levels in limited tissues and hematopoietic cells. None of the four related proteins is expected to bind IgE, which is required for TCTP’s proallergic reactions. These results collectively suggest that they genes play negligible biologic roles in humans.

Keywords: TPT1 gene; Translationally controlled tumor protein; Pseudogenes

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