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Journal of Genital System & DisordersISSN: 2325-9728

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Research Article, J Genit Syst Disor Vol: 4 Issue: 1

The Effect of the Antioxidant Drug U-74389G on Endosalpingeal Edema during Ischemia Reperfusion Injury in Rats

Τsompos C1, Panoulis C2, Τοutouzas K3, Ζografos G3 and Papalois A4
1Department of Obstetrics & gynecology, Mesologi County Hospital, Etoloakarnania, Greece
2Department of Obstetrics & gynecology, Aretaieion Hospital, Athens University, Attiki, Greece
3Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
4Apostolos Papalois: Director, Experimental Research Center, ELPEN Pharmaceuticals, Greece
Corresponding author : Tsompos Constantinos
Consultant A, Department of Obstetrics & Gynecology, Mesologi County Hospital, Mesologi 30200, Etoloakarnania, Greece
Tel: +00302631360237; Fax: 00302106811215
E-mail: [email protected]
Received: August 25, 2014 Accepted: November 11, 2014 Published: November 13, 2014
Citation: Τsompos C, Panoulis C, Τοutouzas K, Ζografos G, Papalois A (2015) The Effect of the Antioxidant Drug “U-74389g” On Endosalpingeal Edema during Ischemia Reperfusion Injury in Rats. J Genit Syst Disor 4:1. doi:10.4172/2325-9728.1000102

Abstract

The Effect of the Antioxidant Drug “U-74389G” on Endosalpingeal Edema during Ischemia Reperfusion Injury in Rats

The aim of this experiment was to study the effects of the antioxidant drug “U-74389G” on rat model, particularly in an ischemia reperfusion protocol. The beneficial or other effects of that molecule were studied estimating the mean Endosalpingeal edema (EE) lesions. 40 rats were used of mean weight 231.875 gr. EE was evaluated 60 min after reperfusion for groups A and C and 120 min after reperfusion for groups B and D. Groups A and B without the drug, but C and D with U-74389G administration. Results were that U-74389G administration non-significantly decreased the EE scores by 0.1 [-0.2393284 - 0.0393284] (p=0.1544). This finding was also in accordance with the result of Wilcoxon signed-rank test (p=0.1573). Reperfusion time non-significantly increased the EE scores by 0.1 [-0.0393284 - 0.2393284] (p=0.1544), also in accordance with Wilcoxon signedrank test (p=0.1573). However, U-74389G administration and reperfusion time together non-significantly decreased the EE scores by 0.0545455 [-0.1389869 - 0.029896] (p=0.1988).

Keywords: U-74389G; Endosalpingeal edema; Reperfusion

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