Journal of Pharmaceutical Sciences & Emerging Drugs ISSN: 2380-9477

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Research Article, J Pharm Sci Emerg Drugs Vol: 3 Issue: 1

The Effect of the Antioxidant Drug 'U-74389G' on Uterus Inflammation during Ischemia Reperfusion Injury in Rats

Τsompos C1*, Panoulis C2, Τοutouzas K3, Ζografos G4 and Papalois A5
1Department of Obstetrics & gynecology, Mesologi County Hospital, Etoloakarnania, Greece
2Department of Obstetrics & gynecology, Aretaieion Hospital, Athens University, Attiki, Greece
3Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
4Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
5Exprerimental Research Center ELPEN Pharmaceuticals, S.A. Inc., Co., Greece
Corresponding author : C. Τsompos
Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania, Greece
Tel: +3026310 57100; Fax: +3026310 57107
E-mail: [email protected]
Received: August 27, 2014 Accepted: March 12, 2015 Published: March 16, 2015
Citation: Tsompos C, Panoulis C, Toutouzas K, Zografos G, Papalois A (2015) The Effect of the Antioxidant Drug “U-74389G” on Uterus Inflammation during Ischemia Reperfusion Injury in Rats. J Pharm Sci Emerg Drugs 3:1. doi:10.4172/2380-9477.1000107

Abstract

This experimental study was to examine the effect of the antioxidant drug “U-74389G”, on rat model and particularly in a uterus ischemia reperfusion (IR) protocol. The beneficial effect or non-effectiveness of that molecule were studied pathologically using uterus inflammation (UI) lesions.40 rats of mean weight 231.875 gr were used in the study. UI lesions were evaluated 60 min after reperfusion (groups A and C) and 120 min after reperfusion with administration of the drug U-74389G in groups C and D.

Keywords: U-74389G; Uterus inflammation; Reperfusion

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