The Effect of the Antioxidant Drug U-74389G on Endosalpingeal Edema during Ischemia Reperfusion Injury in Rats

The Effect of the Antioxidant Drug “U-74389G” on Endosalpingeal Edema during Ischemia Reperfusion Injury in Rats

The aim of this experiment was to study the effects of the antioxidant drug “U-74389G” on rat model, particularly in an ischemia reperfusion protocol. The beneficial or other effects of that molecule were studied estimating the mean Endosalpingeal edema (EE) lesions. 40 rats were used of mean weight 231.875 gr. EE was evaluated 60 min after reperfusion for groups A and C and 120 min after reperfusion for groups B and D. Groups A and B without the drug, but C and D with U-74389G administration. Results were that U-74389G administration non-significantly decreased the EE scores by 0.1 [-0.2393284 - 0.0393284] (p=0.1544). This finding was also in accordance with the result of Wilcoxon signed-rank test (p=0.1573). Reperfusion time non-significantly increased the EE scores by 0.1 [-0.0393284 - 0.2393284] (p=0.1544), also in accordance with Wilcoxon signedrank test (p=0.1573). However, U-74389G administration and reperfusion time together non-significantly decreased the EE scores by 0.0545455 [-0.1389869 - 0.029896] (p=0.1988).