Journal of Genetic Disorders & Genetic Reports ISSN: 2327-5790

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Review Article, J Genet Disor Genet Rep Vol: 5 Issue: 1

Telomeres in Cancer: Length, Positioning and Epigenetics

Patel TN*, Sulekha R Nair, Lekshmi Mohan, Fahmina Y, Ashwini Devi S and VA Saimadhukiran Dabbiru
Division of Medical Biotechnology, SBST, VIT, Vellore 632014, Tamilnadu, India
Corresponding author : TN Patel, Associate Professor
Division of Medical Biotechnology, SBST, VIT, Vellore-632014, Tamilnadu, India
Tel: 9597873669
E-mail: [email protected]
Received: November 03, 2015 Accepted: January 21, 2016 Published: January 27, 2016
Citation: Patel TN, Nair SR, Mohan L, Fahmina Y, AshwiniDevi S, et al. (2016) Telomeres in Cancer: Length, Positioning and Epigenetics. J Genet Disor Genet Rep 5:1. doi:10.4172/2327-5790.1000131

Abstract

Telomeres, the tandem nucleotide sequences at the termini of the DNA, enables the masking of DNA from repair mechanisms, thus protecting them from being considered as double stranded breaks. When the maintenance of telomeres goes awry, several diseases including cancer are resulted. Here in this review, we give an account of how telomere shortening, lengthening, positioning in the nucleus and its associated epigenetic modifications set cancer cells apart from normal cells.

Keywords: Telomere; Telomerase; ALT; BFB cycles; Lamin A/C; HMTases; Epigenesis; Chromatin remodelers

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