International Publisher of Science, Technology and Medicine

 

Lih Kuo

Lih Kuo

Lih Kuo, PhD
Department of Medical Physiology
Texas A&M Health Science Center, USA

 

Biography

  • B.S., Biology, 1979, Tunghai University (Taiwan)
  • M.S., Physiology, 1983, National Taiwan University
  • Ph.D., Physiology, 1987, Medical College of Virginia

Research Interest

My research focuses on the physiological and pathophysiological regulation of coronary and retinal microcirculation. In the circulatory system, the amount of blood delivered to each tissue can be regulated by the activity of arterial microvessels (<100 µm in diameter). Changes in vascular tone, i.e., constriction or dilation of these microvessels, will decrease or increase blood supply to the tissue, respectively. However, the mechanisms involved in the regulation of vascular tone are not completely understood. Our current research focuses on the regulation of microvascular tone by hemodynamic (e.g., pressure and shear stress), metabolic (e.g., adenosine, osmolarity, K+, pH, pO2) and neural (adrenergic receptors) factors. The interplay among these factors and the underlying cellular/subcellular mechanisms in the integrative regulation of coronary and retinal microvascular function are studied. Based on this fundamental information, the pathophysiological disturbances of coronary microvascular function during disease states (e.g., atherosclerosis, septic shock, hypertension, diabetes, and ischemia-reperfusion injury) are investigated using various techniques and approaches including 1) cell culture and isolated vessel for assessing cellular and vascular function, 2) molecular analysis of protein and gene expression, 3) biochemical and pharmacological determination of signaling pathways, 4) fluorescence microscopy and immunohistochemistry for calcium signaling and protein localization, and 5) determination of gene activation and vascular remodeling. To have an integrative view on the flow regulation, this basic information are reconstructed using mathematical model and computer simulation technology. This research provides a basic foundation critical to our understanding of blood flow regulation in the microvascular network under normal and disease states.

Publications

Editors & Editorial Board Members
none:  Mol Med Ther 2012, 1:1
doi: #
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Abstract  |   Full-text  |   PDF  |  
Editors & Editorial Board Members
none:  Mol Med Ther 2012, 1:2
doi:
Abstract  |   Full-text  |   PDF  |  
Human Fungal Infections: Need to Improve Diagnosis with New Biomarkers Developed by Translational Research
Editorial:  Mol Med Ther 2012, 1:1
doi: 10.4172/2324-8769.1000e101
Aamir Shahzad, Randall J Cohrs, Adong Shen and Cornelia Lass-Flörl
Abstract  |   Full-text  |   PDF  |  
Performance of Commercial Interferon-γ Release Assays for Screening Latent Tuberculosis Infection: A Meta-Analysis
Research Article:  Mol Med Ther 2012, 1:2
doi: 10.4172/2324-8769.1000103
Lin Sun, Qingqin Yin, Jianling Tian, Qing Miao, Fang Xu, Jing Xiao, Chen Shen, Weiwei Jiao, Cornelia Lass-Flörl, Aamir Shahzad and Adong Shen
Abstract  |   Full-text  |   PDF  |  
Parkinson’s Disease and Type-2 Diabetes: Methylglyoxal may be a Common Causal Agent; Carnosine could be Protective
Review Article:  Mol Med Ther 2012, 1:2
doi: 10.4172/2324-8769.1000104
Alan R. Hipkiss
Abstract  |   Full-text  |   PDF  |  
Prolyl Hydroxylases in fight or flight
Editorial:  Mol Med Ther 2012, 1:1
doi: 10.4172/2324-8769.1000e102
Anne-Theres Henze, Rodrigo Leite de Oliveira and Massimiliano Mazzone
Abstract  |   Full-text  |   PDF  |  
Genome-Scale Mapping of MicroRNA Signatures in Human Embryonic Stem Cell Neurogenesis
Research Article:  Mol Med Ther 2012, 1:2
doi: 10.4172/2324-8769.1000105
Xuejun H. Parsons, James F. Parsons and Dennis A. Moore
Abstract  |   Full-text  |   PDF  |  
Regulation of Coronary Vasomotor Function by Reactive Oxygen Species
Review Article:  Mol Med Ther 2012, 1:1
doi: 10.4172/2324-8769.1000101
Lih Kuo, Naris Thengchaisri and Travis W. Hein
Abstract  |   Full-text  |   PDF  |  
Novel Combinatorial Therapeutic Targeting of PAI-1(SERPINE1) Gene Expression in Alzheimer’s Disease
Short Communication:  Mol Med Ther 2012, 1:2
doi: 10.4172/2324-8769.1000106
Stacie M. Kutz, Craig E. Higgins and Paul J. Higgins
Abstract  |   Full-text  |   PDF  |  
Low Molecular Weight Antagonists of Plasminogen Activator Inhibitor-1: Therapeutic Potential in Cardiovascular Disease
Short Communication:  Mol Med Ther 2012, 1:1
doi: 10.4172/2324-8769.1000102
Tessa M. Simone and Paul J. Higgins
Abstract  |   Full-text  |   PDF  |  
 
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