International Publisher of Science, Technology and Medicine

 

Mikhail Kolonin

Mikhail Kolonin

Mikhail Kolonin, PhD
Center For Metabolic and Degenerative Diseases
University of Texas Health Science Center at Houston, USA

 

Biography

Dr. Mikhail Kolonin, received his B.S./M.S. degree from Novosibirsk State University (Russia) and Ph.D. from Wayne State University (Detroit, MI) where he has pioneered the concept of expressing small peptides designed to disrupt specific protein interactions in live animals using Drosophila as a model. As a post-doctoral fellow at M.D. Anderson Cancer Center, he has optimized in vivo phage display technology to isolate differentially expressed vascular cell surface molecules by integrating molecular biology of angiogenesis with bioinformatics. This work, first initiated in the mouse model and then translated to screens in cancer patients, has led to several tissue-specific cell surface protein interactions that are now pursued as therapy targets. A drug prototype based on a peptide targeting interleukin-11 receptor in the prostate is in clinical trials. Based on peptide-directed drug delivery, Dr. Kolonin also co-invented an approach to obesity reversal through directed ablation of white fat vasculature. A compound targeting prohibitin protein on the surface of adipose endothelium (Adipotide), currently under commercial development, has proven effective as an experimental obesity drug in rodent and non-human primate models.

Research Interest

Research in the Kolonin Laboratory converges on stem cells, obesity, and cancer. Specifically, the focus is on intercellular interactions in adipose tissues and tumors and the role of adult progenitor cells in pathology. These studies are based on the analysis of clinical specimens and mouse models. Dr. Kolonin and colleagues have discovered the phenomenon of adipose cell mobilization and trafficking to tumors and the stimulatory effect of adipose stromal cells on cancer progression. These findings have provided new insights on the association between obesity and cancer. The molecular mechanisms of adipose cell migration to tumors and their role in tumor microenvironment are under investigation. The group expertise in cell population separation and identification of tissue-specific cell surface receptors has led to the recent identification of delta-decorin as the first known marker selectively expressed on adipose progenitor cells. An agent designed to target adipose progenitor cells through binding to delta-decorin is being pre-clinically tested for long-term treatment of obesity and a combination cancer therapy. Other projects are focused on identification of molecules targeting brown adipose tissue for whole body imaging applications, adipose tissue engineering in three-dimensional culture, identification of liposarcoma-initiating cells, and exploring the role of adipose tissue in leukemia progression.

Publications

Editors & Editorial Board Members
none:  Mol Med Ther 2012, 1:1
doi: #
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Abstract  |   Full-text  |   PDF  |  
Editors & Editorial Board Members
none:  Mol Med Ther 2012, 1:2
doi:
Abstract  |   Full-text  |   PDF  |  
Human Fungal Infections: Need to Improve Diagnosis with New Biomarkers Developed by Translational Research
Editorial:  Mol Med Ther 2012, 1:1
doi: 10.4172/2324-8769.1000e101
Aamir Shahzad, Randall J Cohrs, Adong Shen and Cornelia Lass-Flörl
Abstract  |   Full-text  |   PDF  |  
Performance of Commercial Interferon-γ Release Assays for Screening Latent Tuberculosis Infection: A Meta-Analysis
Research Article:  Mol Med Ther 2012, 1:2
doi: 10.4172/2324-8769.1000103
Lin Sun, Qingqin Yin, Jianling Tian, Qing Miao, Fang Xu, Jing Xiao, Chen Shen, Weiwei Jiao, Cornelia Lass-Flörl, Aamir Shahzad and Adong Shen
Abstract  |   Full-text  |   PDF  |  
Parkinson’s Disease and Type-2 Diabetes: Methylglyoxal may be a Common Causal Agent; Carnosine could be Protective
Review Article:  Mol Med Ther 2012, 1:2
doi: 10.4172/2324-8769.1000104
Alan R. Hipkiss
Abstract  |   Full-text  |   PDF  |  
Prolyl Hydroxylases in fight or flight
Editorial:  Mol Med Ther 2012, 1:1
doi: 10.4172/2324-8769.1000e102
Anne-Theres Henze, Rodrigo Leite de Oliveira and Massimiliano Mazzone
Abstract  |   Full-text  |   PDF  |  
Genome-Scale Mapping of MicroRNA Signatures in Human Embryonic Stem Cell Neurogenesis
Research Article:  Mol Med Ther 2012, 1:2
doi: 10.4172/2324-8769.1000105
Xuejun H. Parsons, James F. Parsons and Dennis A. Moore
Abstract  |   Full-text  |   PDF  |  
Regulation of Coronary Vasomotor Function by Reactive Oxygen Species
Review Article:  Mol Med Ther 2012, 1:1
doi: 10.4172/2324-8769.1000101
Lih Kuo, Naris Thengchaisri and Travis W. Hein
Abstract  |   Full-text  |   PDF  |  
Novel Combinatorial Therapeutic Targeting of PAI-1(SERPINE1) Gene Expression in Alzheimer’s Disease
Short Communication:  Mol Med Ther 2012, 1:2
doi: 10.4172/2324-8769.1000106
Stacie M. Kutz, Craig E. Higgins and Paul J. Higgins
Abstract  |   Full-text  |   PDF  |  
Low Molecular Weight Antagonists of Plasminogen Activator Inhibitor-1: Therapeutic Potential in Cardiovascular Disease
Short Communication:  Mol Med Ther 2012, 1:1
doi: 10.4172/2324-8769.1000102
Tessa M. Simone and Paul J. Higgins
Abstract  |   Full-text  |   PDF  |  
 
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