Journal of Pharmaceutical Sciences & Emerging Drugs ISSN: 2380-9477

Research Article, J Pharm Sci Emerg Drugs Vol: 4 Issue: 1

An In Vitro Study of Binding of Aceclofenac and Pantoprazole with Bovine Serum Albumin by UV Spectroscopic Method

Sabiha Ferdowsy Koly1, Md. Zakir Sultan2, Asma Rahman2, Shaila Kabir1 and Mohammad Shah Amran1*
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
2Centre for Advanced Research in Sciences, University of Dhaka, Dhaka-1000,Bangladesh
Corresponding author : Md. Shah Amran
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
Tel: +8801718617915
E-mail: [email protected]
Received: May 22, 2015 Accepted: December 29, 2015 Published: January 04, 2016
Citation: Koly SF, Sultan Md.Z, Rahman A, Kabir S, Amran MS (2016) An In Vitro Study of Binding of Aceclofenac and Pantoprazole with Bovine Serum Albumin by UV Spectroscopic Method. J Pharm Sci Emerg Drugs 4:1 doi:10.4172/2380-9477.1000109

Abstract

An In Vitro Study of Binding of Aceclofenac and Pantoprazole with Bovine Serum Albumin by UV Spectroscopic Method

Plasma protein binding is one of the most important pharmacokinetic parameter of drug. The study was designed to determine the binding of Aceclofenac and Pantoprazole to Bovine Serum Albumin. The study was conducted by equilibrium dialysis method followed by measurement using a spectrophotometer at pH 7.4 and 37°C

Keywords: Bovine serum albumin (BSA); Aceclofenac; Pantoprazole; Protein binding; Equilibrium dialysis

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