Journal of Pharmaceutical Sciences & Emerging Drugs ISSN: 2380-9477

Research Article, J Pharm Sci Emerg Drugs Vol: 4 Issue: 2

Antibacterial Activity of Selected Essential oils against Streptococcus sobrinus and Porphyromonas gingivalis

Xiaoyu Wang1,2, Tohru Mitsunaga1*, and Kosei Yamauch
1Institute of Pesticide & Environmental Toxicology, Guangxi University, Nanning 530005, China
2Faculty of Applied Biological Science, Gifu University, Gifu, Japan
Corresponding author : Tohru Mitsunaga
Faculty of Applied Biological Science, Department of Applied Life Science, Gifu University, Japan
Tel: +81-058-293-2920
Fax: +81-058-293-2920
E-mail: [email protected]
Received: March 04, 2016 Accepted: May 02, 2016 Published: May 15, 2016
Citation: Wang X, Mitsunaga T, Yamauchi K (2016) Antibacterial Activity of Selected Essential oils against Streptococcus sobrinus and Porphyromonas gingivalis. J Pharm Sci Emerg Drugs 4:2. doi: 10.4172/2380-9477.1000113


Plant essential oils have been used medicinally in history. The antibacterial screening of selected plant essential oils against Porphyromonas gingivalis and Streptococcus sobrinus was evaluated by MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) assay. Among them, thujopsis dolabrata (Asunaro) essential oil was selected as a fairly effective sample against P. gingivalis (MIC=1 mg/ml) and S. sobrinus (MIC=1 mg/ml) respectively. Moreover, Callitrisintratropica (Australian blue cypress; cypress) was also screened as a fairly effective sample only against S. sobrinus (MIC=0.5 mg/ml). Furthermore, five effective compounds, (+)-cuparene, (-)-thujopsene, (+)-cuparenol, (-)-guaiol and a novel sesquiterpenoid were isolated by a performance of a series of chromatography, and identified by nuclear magnetic resonance (NMR) and matrix assisted laser desorption/ionizationtime of flight mass spectrometry (MALDI-TOFMS). Among them, (+)-cuparenol was the most effective compound with a MIC of 0.125 mg/ml against P. gingivais. Additionally, the novel sesquiterpenoid (MIC=0.25 mg/ml) was identified as the first time isolation from C. intratropica.

Keywords: Thujopsis dolabrata; Callitris intratropica; Porphyromonas gingivalis; Streptococcus sobrinus;(+)-cuparene; (-)-thujopsene;(+)-cuparenol;(-)-guaiol; novel sesquiterpenoid

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