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Journal of Pharmaceutical Sciences & Emerging Drugs ISSN: 2380-9477

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Research Article, J Pharm Sci Emerg Drugs Vol: 7 Issue: 1

Assessment of Phytochemical and Antidiabetic Potential of Fruits of Pedalium murex in Alloxan induced Diabetic Rat Model

Manoj Kumar Sahu1, Ashish Manigauha1* and Ram Kumar Sahu2

1Department of Pharmacology, Technocrats Institute of Technology-Pharmacy, Anand Nagar, Bhopal 462021, India

2University College of Pharmacy, Pt. Deendayal Upadhyay Memorial Health Sciences Ayush University of Chhattisgarh, Raipur, India

*Corresponding Author : Ashish Manigauha
Department of Pharmacology, Technocrats Institute of Technology-Pharmacy, Anand Nagar, Bhopal 462021, India
E-mail: [email protected]

Received: November 14, 2018 Accepted: February 25 2019 Published: March 08, 2019

Citation: Sahu MK, Manigauha A, Sahu RK (2019) Assessment of Phytochemical and Antidiabetic Potential of Fruits of Pedalium murex in Alloxan induced Diabetic Rat Model. J Pharm Sci Emerg Drugs 7:1.

Abstract

Pedalium murex is utilized for the fix of ulcers, fevers, puerperal sicknesses, wounds, general debility, diabetes, stomach related tonics and disarranges by inborn people groups of India. The antidiabetic activity of Pedalium murex fruit extract was scientifically not reported. Hence it was planned to evaluate the phytochemical and antidiabetic activity of Pedalium murex fruit extracts. The petroleum ether and ethanol extracts were prepared and processed for further studies. The petroleum ether and ethanol extracts were evaluated for phytochemical screening. The maximum phytocostituents were observed in ethanol extracts of fruits of Pedalium murex. The oral acute toxicity study of ethanol extract of Pedalium murex fruit was evaluated, and found to be safe. The ethanol extract of Pedalium murex fruit (100 mg/kg and 200 mg/kg body weight) managed orally in Alloxanprompted diabetic rodents. After the organization of extract, blood glucose levels were observed at explicit interims and it was discovered that they were noteworthy brought down. The impact of extracts on prompted hyperlipidemia was investigated where the extracts essentially brought down the lifted all out cholesterol, triglycerides (TGL) and low density lipoprotein (LDL) leve while expanded the High density lipoprotein (HDL). The exploratory information uncovered that remove has huge antidiabetic activity in alloxan-prompted rodents.

Keywords: Pedalium murex; Alloxan; Antidiabetic; Phytochemical; Fruits; Cholesterol; Triglycerides

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