Journal of Pharmaceutical Sciences & Emerging Drugs ISSN: 2380-9477

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article, J Pharm Sci Emerg Drugs Vol: 4 Issue: 1

Characterization of Darunavir: Β-Cyclodextrin complex and Comparison with the Forms of Darunavir Ethanolate and Hydrate

Ana Carolina Kogawa1*, Selma Gutierrez Antonio2, Hérida Regina Nunes Salgado1
1Department of Pharmaceutics, School of Pharmaceutical Sciences of Araraquara, Univ Estadual Paulista - UNESP, Araraquara, São Paulo, Brazil
2Department of Physical Chemistry, Institute of Chemistry, Univ Estadual Paulista - UNESP, Araraquara, São Paulo, Brazil
Corresponding author : Ana Carolina Kogawa
Department of Pharmaceutics, School of Pharmaceutical Sciences of Araraquara, Univ Estadual Paulista - UNESP, Araraquara, São Paulo, Brazil
Tel: +55 16 3301 4681; Fax: +55 16 3301 6967
E-mail: [email protected]
Received: August 24, 2015 Accepted: December 28, 2015 Published: January  04, 2015
Citation: Kogawa AC, Antonio SG, Salgado HRN (2016) Characterization of Darunavir: Β-Cyclodextrin complex and Comparison with the Forms of Darunavir Ethanolate and Hydrate. J Pharm Sci Emerg Drugs 4:1 doi:10.4172/2380-9477.1000110

 

Abstract

Characterization of Darunavir: Β-Cyclodextrin complex and Comparison with the Forms of Darunavir Ethanolate and Hydrate

Darunavir, a protease inhibitor used in the treatment of HIV infection, presents solubility problems and so it was complexed with β-cyclodextrin. Complexation increased the solubility of the drug in more than 28 times compared to the free drug. Then, it is important to characterize this recent advance of pharmaceutical technology as well as its comparison with the forms of free darunavir, hydrate and ethanolate. Spectroscopy in the infrared (IR), thermal techniques of thermogravimetry (TG) and differential scanning calorimetry with heat flux (DSC) and X-ray powder diffraction were elected for the characterization of darunavir:β-cyclodextrin complex and comparison with darunavir ethanolate and darunavir hydrate.

Keywords: Darunavir: β-cyclodextrin; Darunavir ethanolate; Darunavir hydrate; differential scanning calorimetry; Infrared; Thermogravimetry; X-ray diffraction

Track Your Manuscript

Share This Page