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Hindi Research Article, J Pharm Sci Emerg Drugs Vol: 4 Issue: 1
Characterization of Darunavir: Î’-Cyclodextrin complex and Comparison with the Forms of Darunavir Ethanolate and Hydrate
| Ana Carolina Kogawa1*, Selma Gutierrez Antonio2, Hérida Regina Nunes Salgado1 | |
| 1Department of Pharmaceutics, School of Pharmaceutical Sciences of Araraquara, Univ Estadual Paulista - UNESP, Araraquara, São Paulo, Brazil | |
| 2Department of Physical Chemistry, Institute of Chemistry, Univ Estadual Paulista - UNESP, Araraquara, São Paulo, Brazil | |
| Corresponding author : Ana Carolina Kogawa Department of Pharmaceutics, School of Pharmaceutical Sciences of Araraquara, Univ Estadual Paulista - UNESP, Araraquara, São Paulo, Brazil Tel: +55 16 3301 4681; Fax: +55 16 3301 6967 E-mail: ac_kogawa@yahoo.com.br |
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| Received: August 24, 2015 Accepted: December 28, 2015 Published: January 04, 2015 | |
| Citation: Kogawa AC, Antonio SG, Salgado HRN (2016) Characterization of Darunavir: Β-Cyclodextrin complex and Comparison with the Forms of Darunavir Ethanolate and Hydrate. J Pharm Sci Emerg Drugs 4:1 doi:10.4172/2380-9477.1000110 |
Abstract
Characterization of Darunavir: Β-Cyclodextrin complex and Comparison with the Forms of Darunavir Ethanolate and Hydrate
Darunavir, a protease inhibitor used in the treatment of HIV infection, presents solubility problems and so it was complexed with β-cyclodextrin. Complexation increased the solubility of the drug in more than 28 times compared to the free drug. Then, it is important to characterize this recent advance of pharmaceutical technology as well as its comparison with the forms of free darunavir, hydrate and ethanolate. Spectroscopy in the infrared (IR), thermal techniques of thermogravimetry (TG) and differential scanning calorimetry with heat flux (DSC) and X-ray powder diffraction were elected for the characterization of darunavir:β-cyclodextrin complex and comparison with darunavir ethanolate and darunavir hydrate.
