Journal of Pharmaceutical Sciences & Emerging Drugs ISSN: 2380-9477

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Research Article, J Pharm Sci Emerg Drugs Vol: 5 Issue: 1

Evaluation of Nanoparticles as Carrier for Bacillus Stearothermophilus Spore Preservation in Bioindicator System

Mohsen Lotfi1*, Neda Eskandari2 and Fatemeh Mohammadipanah2

1Department of Quality Control, Razi Vaccine and Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran

2Department of Microbial Biotechnology, School of Biology and Center of Excellence in Phylogeny of Living Organisms, College of Science, University of Tehran, Iran

*Corresponding Author : Mohsen Lotfi
Department of Quality Control, Razi Vaccine and Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran
Tel: +989122654771
E-mail:
[email protected]

Received: June 13, 2017 Accepted: April 08, 2017 Published: April 15, 2017

Citation: Lotfi M, Eskandari N, Mohammadipanah F (2017) Evaluation of Nanoparticles as Carrier for Bacillus Stearothermophilus Spore Preservation in Bioindicator System. J Pharm Sci Emerg Drugs 5:1. doi:10.4172/2380-9477.1000122

Abstract

A precise assessment of sterilization processes is very essential in the pharmaceutical and biological industry, because a wrong treatment could result in the spoilage of a product due to microorganism development. Bacillus Stearothermophilus has been established as an industrial bacterium in the production of biological sterilization indicators. The production of biological indicators involving bacterial spore production which is dormant and are extremely resistant to heat stresses. Bacillus Stearothermophilus ATCC 7953 spores are used to monitor the efficacy of steam heat and hydrogen peroxide sterilization processes. In this study, efficacy of replacing nanomaterial as carrier instead of regular paper strip was investigated. For this purpose, the effect of nanomaterial on thermal resistance parameters and spore absorption was assessed and compared with common paper strips of this product.

Keywords: Nanoparticles; Bacillus stearothermophilus; Bioindicator system; Sterilization processes; Pharmaceutical industry

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