Journal of Pharmaceutical Sciences & Emerging Drugs ISSN: 2380-9477

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article, J Pharm Sci Emerg Drugs Vol: 4 Issue: 1

Evaluation of the Potential of Natural Biodegradable Polymers(Echinochloa Colonum Starch) and its Derivatives in Aqueous Coating of Hydrophilic Drugs

Dinesh M Pardhi1*, Herida Regina Nunes Salgado1, Sumitra Nain2
1Universidade Estadual Paulista Júlio de Mesquita Filho- UNESP, Rodovia Araraquara/Jaú Km 1CEP: 14800-901Caixa Postal - 174, Araraquara, Brazil
2Department of Pharmacy, Banasthali University, Banasthali, Rajasthan-304022, India.
Corresponding author : Dinesh M Pardhi
Universidade Estadual Paulista Júlio de Mesquita Filho- UNESP, Rodovia Araraquara/Jaú Km 1CEP: 14800-901Caixa Postal - 174, Araraquara, Brazil
Tel: +5516997189199
E-mail: [email protected]
Received: September 17, 2015 Accepted: February 03, 2016 Published: February 08, 2016
Citation: Pardhi D, Salgado H, Nain S (2016) Evaluation of the Potential of Natural Biodegradable Polymers (Echinochloa Colonum Starch) and its Derivatives in Aqueous Coating of Hydrophilic Drugs. J Pharm Sci Emerg Drugs 4:1. doi:10.4172/2380-9477.1000112

Abstract

Evaluation of the Potential of Natural Biodegradable Polymers (Echinochloa Colonum Starch) and its Derivatives in Aqueous Coating of Hydrophilic Drugs

The two starch derivatives viz. acetyl starch and Carboxymethylated starch (CMS) were prepared in the laboratory. These derivatives and starch evaluated for their film forming and coating properties. The Metformin Hydrochloride, Acetyl Salicylic Acid, Ascorbic Acid were selected as model drugs as they are moisture sensitive for the preparation of core tablets. The prepared core tablets were coated with Echinochloa colonum pure starch, its acetyl and carboxy methyalted derivative. Physical properties viz., microscopy, swelling capacity, bulk density, tapped density, packing fraction of Echinochloa colonum were better than its other derivatives. Amylase content and film characteristics of pure starch were better. The coated tablets were evaluated for mechanical and chemical properties. It was observed that Carboxymethylated starch of Echinochloa colonum successfully sustained the drug release above 10 hours with excellent mechanical and chemical properties.

Keywords: Amylose; Echinochloa colonum; Moisture sensitive; Starch; Tensile strength

Track Your Manuscript

Share This Page