Journal of Pharmaceutical Sciences & Emerging DrugsISSN: 2380-9477

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Research Article, J Pharm Sci Emerg Drugs Vol: 4 Issue: 1

Pentachlorophenol-Induced Oocyte Maturation in Catfish Heteropneustes Fossils: An In Vitro Study Correlating with Changes in Steroid Profiles

Radha Chaube1*, Abhay Kumar Pandey2 and Sunanda Dubey2
1Zoology Department, Mahila Mahavidyalaya, Banaras Hindu University, India
2Zoology Department, Udai Pratap Autonomous College, Varanasi, India
Corresponding author : Radha Chaube
Zoology Department, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi-221005, U.P, India
E-mail: chauberadha@rediffmail.com

Received: December 12, 2013 Accepted: January 03, 2016 Published: January 08, 2016

Citation: Chaube R, Pandey AK, Dubey S (2016) Pentachlorophenol-Induced Oocyte Maturation in Catfish Heteropneustes Fossils: An In Vitro Study Correlating with Changes in Steroid Profiles. J Pharm Sci Emerg Drugs 4:1. doi:10.4172/2380-9477.1000111

Abstract

Pentachlorophenol-Induced Oocyte Maturation in Catfish Heteropneustes Fossils: An In Vitro Study Correlating with Changes in Steroid Profiles

Pentachlorophenol (PCP) is an organochlorine compound widely used as a biocide and a disinfectant. Its extensive use and persistence have resulted in significant threat to aquatic animals especially fish. In the present study, we report in vitro effects of PCP on oocyte maturation and ovulation, correlating with changes in steroid hormones such as estradiol-17β (E2), testosterone (T), progesterone (P4) and cortisol in the catfish Heteropneustes fossilis. Fully matured post-vitellogenic ovarian follicles were incubated with different concentrations of PCP. PCP stimulated both germinal vesicle breakdown (GVBD) and ovulation, associated with increase or decrease in T, E2, P4 and cortisol levels in a concentration- and duration dependent manner. Thus, PCP down regulated C-18-C19 steroids (E2-Testosterone) and up-regulated C21 steroids (cortisol and P4). These results suggest that PCP acts as a potential endocrine-disrupting chemical that can modulate catfish reproduction.

Keywords: Aquatic pollution, Catfish; Endocrine disruptors; Oocyte maturation; Ovulation; Steroids

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