Journal of Pharmaceutical Sciences & Emerging Drugs ISSN: 2380-9477

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Research Article, J Pharm Sci Emerg Drugs Vol: 2 Issue: 1

Release Kinetics of Cellulosic Nano particulate Formulation for Oral Administration of an Antiviral Drug: Effect of Process and Formulation variables

Deep R Naik, Anand J Patel and Jignesh P Raval*
Department of Chemistry, Uka Tarsadia University, Maliba Campus, Gopal Vidyanagar, Bardoli-Mahuva Road, Tarsadi- 394 350, Tal: Mahuva, Dist: Surat, Gujarat, India
Corresponding author : Dr. Jignesh P. Raval
Department of Chemistry Uka Tarsadia University Bardoli, Surat, Gujarat, India
Tel: +91 2625 – 254122, +919427946892
E-mail: [email protected]
Received: September 26, 2014 Accepted: December 01, 2014 Published: December 05, 2014
Citation: Naik DR, Patel AJ, Raval JP (2014) Release Kinetics of Cellulosic Nano particulate Formulation for Oral Administration of an Antiviral Drug: Effect of Process and Formulation variables. J Pharm Sci Emerg Drugs 2:1. doi:10.4172/2380-9477.1000105

Abstract

Release Kinetics of Cellulosic Nano particulate Formulation forOral Administration of anAntiviral Drug: Effect of Process and Formulation variables

Recently, researchers have increasing interest in cellulosic polymers for optimizing the efficiency of existing drugs utilizing better-designed drug delivery systems. In the present research nanoparticles were prepared using cellulose esters to obtain a drug product with a good oral bioavailability and biological half life. Acyclovir (ACY) was formulated by combining the modified solvent evaporation/extraction technique, sonicator and high pressure homogenization approaches. Various formulation parameters such as sonication-time, concentration of cellulose esters and surfactants were studied. Nanoparticles were obtained with enhanced encapsulation efficiency, negatively charged, defined shape, size and with homogeneous size distribution.

Keywords: Acyclovir; Cellulose esters; Nanoparticles; Modified solvent evaporation/extraction technique; Release kinetic models

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