Dr. Zhang joins the Texas Therapeutic Institute and The Brown Foundation Institute of Molecular Medicine (IMM) at UTHealth from Merck Research Laboratory where she was a research fellow.
Dr. Zhang received her Ph.D. in plant biochemistry/molecular biology from the University of Kentucky, Lexington. She conducted her postdoctoral training at the University of Wisconsin-Madison in Dr. Berne Jones laboratory studying the expression and characterization of proteinases during the brewing process. Following her postdoctoral training, Dr. Zhang pursued a career in the pharmaceutical industry with a focus on protein engineering and therapeutic antibody drug discovery research.
The proteolytic process mediated by proteinases including matrix metalloproteinases (MMPs) in the tumor microenvironment plays a critical role in tumor growth, invasion, metastasis, and cancer drug resistance. The molecular mechanisms underlining the complex roles of proteinases in cancer biology are currently poorly understood. Recent studies suggest that proteinases in tumor microenvironment may invade host immunosurveillance by cleavage of antibodies or shedding cell surface receptors to allow cancer cells to escape immune response. Dr. Zhang will study the interactions between proteinases and anti-tumor antibodies in the tumor microenvironment to delineate the roles of proteinses play in tumor resistance to antibody immune therapies.
Human Fungal Infections: Need to Improve Diagnosis with New Biomarkers Developed by Translational ResearchEditorial: Mol Med Ther 2012, 1:1
Aamir Shahzad, Randall J Cohrs, Adong Shen and Cornelia Lass-Flörl
Performance of Commercial Interferon-γ Release Assays for Screening Latent Tuberculosis Infection: A Meta-AnalysisResearch Article: Mol Med Ther 2012, 1:2
Lin Sun, Qingqin Yin, Jianling Tian, Qing Miao, Fang Xu, Jing Xiao, Chen Shen, Weiwei Jiao, Cornelia Lass-Flörl, Aamir Shahzad and Adong Shen
Parkinsons Disease and Type-2 Diabetes: Methylglyoxal may be a Common Causal Agent; Carnosine could be ProtectiveReview Article: Mol Med Ther 2012, 1:2
Alan R. Hipkiss
- Editorial: Mol Med Ther 2012, 1:1
Anne-Theres Henze, Rodrigo Leite de Oliveira and Massimiliano Mazzone
- Research Article: Mol Med Ther 2012, 1:2
Xuejun H. Parsons, James F. Parsons and Dennis A. Moore
- Review Article: Mol Med Ther 2012, 1:1
Lih Kuo, Naris Thengchaisri and Travis W. Hein
- Short Communication: Mol Med Ther 2012, 1:2
Stacie M. Kutz, Craig E. Higgins and Paul J. Higgins
Low Molecular Weight Antagonists of Plasminogen Activator Inhibitor-1: Therapeutic Potential in Cardiovascular DiseaseShort Communication: Mol Med Ther 2012, 1:1
Tessa M. Simone and Paul J. Higgins