Dr. Matin's laboratory studies improvment in prodrug cancer chemotherapy; genetic and protein engineering to improve biological processes, such as bioremediation; microbial biofilms; cellular resistance to antimicrobial agents; and microbial stress response. Recent progress of the laboratory are: The ChrR enzyme has been crystallized and new improved mutants were obtained by rational design. Magnetite genes were expressed in mammalian cells. PK/PD studies of CNOB/ChrR anticancer therapy were completed. A new paradigm was worked out of bacterial sensitivity to antibiotics. In collaboration with NASA (Moffett Field) a protocol was developed to test hypotheses for increased bacterial antibiotic resistance by microgavity during actual space flight on board a small satellite

  Translational cancer research Bacterial antibiotic resistance