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Samuel De visse

Samuel De visse

Samuel De visser
University of Manchester, UK

 

Biography

Samuel De visser currently holds a position of Senior Lecturer in University of Manchester, UK. He has more than 50 publications. He has many research articles on Oxidative stress. His are articles are most viewed articles of oxidative stress.

Research Interest

Oxidative stress & Oxidative properties of heme and nonheme enzymes. Nature contains many enzymes that utilize molecular oxygen on an iron center, namely there a large group of enzymes with a heme central ligand but also many enzymes with non-heme ligands. Often the active species that performs the oxidation reactions is an oxo-iron(IV) species, which has been trapped and characterized in the nonheme enzyme taurine/alpha-ketoglutarate dioxygenase but is elusive in the cytochromes P450. Thus, theoretical modeling as done in our group gives important answers to questions such as: What is the active oxidant in the enzyme and what are the mechanisms of substrate monoxygenation? In the past we have done many detailed density functional theory and quantum mechanics/molecular mechanics studies into the nature of substrate oxidation by heme and nonheme enzymes.Among the heme-ligated oxo-iron species are enzymes such as the cytochromes P450, catalases and peroxidases. These enzymes all have seemingly similar active sites but totally different functions in biosystems. Thus, the P450s catalyze the metabolism of drugs and are involved in the detoxification of xenobiotics and the biosynthesis of hormones. By contrast, the catalases reduce hydrogen peroxide to water. In our group we extensively studied the electronic factors that influence the catalytic properties of heme and non-heme enzymes using model complexes and quantum mechanical / molecular mechanical (QM/MM) techniques. Our studies have shown how small structural differences in the active site of enzymes result in dramatic differences in reactivity patterns. Recently, a valence bond curve crossing model was set-up that describes the hydroxylation mechanism of substrates by the oxo-iron(IV) oxidant of P450 enzymes. Other heme enzymes, we recently started working on are the nitric oxide synthase class of enzymes that are involved in the biosynthesis of NO in the body through oxidation of arginine. We have established a new mechanism and assigned a possible oxidant of the reaction.Other studies in our group focused on the differences and comparisons of substrate monoxygenation by heme and nonheme oxo-iron(IV) oxidants. Thus, in order to make a fair comparison we studied the same reaction mechanism by models of taurine/α-ketoglutarate dioxygenase (TauD) and cytochrome P450 using propene as a substrate. As shown, both models give competing C-H hydroxylation and C=C epoxidation mechanisms. However, the barriers as obtained for α-ketoglutarate dioxygenase are lower by 7.5 kcal mol-1 with respect to cytochrome P450. Those studies implied that non-heme oxo-iron complexes as appear in α-ketoglutarate dioxygenase are much more aggressive oxidants than oxo-iron heme enzymes. Therefore, our studies have given insight into the nature of high valent oxo-iron oxidants and their reactivity patterns with respect to a broad range of substrates. These studies give insight into the way nature catalyzes important reaction mechanisms.

Publications

Effects of Acute Consumption of Garcinia kola on Hepatic Enzymes in Apparently Well Nigerian Youths
Research Article:  J Proteomics Enzymol 2016, 5:1
doi: 10.4172/2470-1289.1000125

Biliaminu SA, Abdul Azeez, Abdur Rahman MB and Ajani S

Abstract  |   Full-text  |   PDF  |  
A Network-Based Analysis of Proteins Involved In Hypoxia Stress and Identification of Leader Proteins
Research Article:  J Proteomics Enzymol 2016, 5:1
doi: 10.4172/2470-1289.1000126

Pankaj Khurana, Sugadev R, Soma Sarkar and Shashi Bala Singh

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Purification and Characterization of Heparin Binding Proteins from Seminal Plasma of Cross- bred Cattle Bulls by Affinity Chromatography, SDS-PAGE and Mass Spectrometery
Research Article:  J Proteomics Enzymol
doi: 10.4172/2470-1289.1000127
Ranjna S Cheema, Amrit K Bansal, Maulik Patel and VK Gandotra
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Editors & Editorial Board Members
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Cellulase and Xylanase Production by a Novel Strain of Rhizopus oryzae W2 (JX129361.1) Isolated from Compost Utilizing Agro Forest Residues under Solid State Fermentation
Research Article:  J Proteomics Enzymol
doi: 10.4172/2470-1289.1000117

Sanjeev Kumar , Nivedita Sharma and DivyaTandon

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none:  J Biocatal Biotransformation 2013, 2:1
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Modeling of Esterase from "Saccharomyces cerevisiae" and Evaluation of the Antimicrobial Activities of the Enzyme Products
Research Article:  J Biocatal Biotransformation 2014, 3:1
doi: 10.4172/2324-9099.1000112
Rabaa Ben Asker, Najla Ben Akacha and Belgacem Hanchi
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Tandem Mass Spectrometry Analysis as an Approach to Delineate Genetically Related Taxa, with Specific Implication for Differentiating Escherichia coli from amongst the Complex Enterobacteriaceae Family
Research Article:  J Proteomics Enzymol
doi: 10.4172/2470-1289.1000121
Raju V Misra , Tom Gaulton , Min Fang , Renata Culak , Martin Hornshaw , Jenny Ho , Saheer E Gharbia and Haroun N Shah
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DNA Hybrid Catalysts for Asymmetric Synthesis
Editorial:  J Biocatal Biotransformation 2012, 1:1
doi: 10.4172/2324-9099.1000e101
Soyoung Park
Abstract  |   Full-text  |   PDF  |  
Xylan Degrading Enzymes from Fungal Sources
Review Article:  J Proteomics Enzymol
doi: 10.4172/2470-1289.1000118

Kirikyali N and Connerton IF

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Parametric Optimization of Extracellular Chitin Deacetylase Production by Scopulariopsis brevicaulis
Research Article:  J Biocatal Biotransformation 2013, 2:1
doi: 10.4172/2324-9099.1000103
Jun Cai, Jin Li, Changgao Wang, Jianguo Lin, Ying Hu, Jianhong Yang, Yumin Du and Hua Zheng
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Rare Sugars: Applications and Enzymatic Production
Editorial:  J Biocatal Biotransformation 2012, 1:2
doi: 10.4172/2324-9099.1000e105
Shuang-Yan Tang
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Optimization of ProcessParameters for Cellulase Free Xylanase Production by Bacillusamyloliquefaciens SH8 in Submerged Fermentation Using Response Surface Methodology
Research Article:  J Biocatal Biotransformation 2014, 3:1
doi: 10.4172/2324-9099.1000113
Sanjeev Kumar, Nivedita Sharma, Gitanjali Vyas* and Divya Tandon
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Characterization of Protein Complexes and Their Implication in Biological Processes
Review Article:  J Proteomics Enzymol
doi: 10.4172/2470-1289.1000122
Mohamed Abu-Farha , Kazem Behbehani and Jehad Abu baker
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Isolation, Purification and Characterization of Fungal Extracellular L-Asparaginase from Mucor hiemalis
Research Article:  J Biocatal Biotransformation 2013, 2:2
doi: 10.4172/2324-9099.1000108
Monica Thakur, Lynette Lincoln, Francois N Niyonzima and Sunil S More
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Tyrosinase and Tyrosinase Inhibitors
Editorial:  J Biocatal Biotransformation 2012, 1:2
doi: 10.4172/2324-9099.1000e106
Tsong-Min Chang
Abstract  |   Full-text  |   PDF  |  
Novel Application of Cucurbita maxima Peel Protease in Detergents
Research Article:  J Proteomics Enzymol
doi: 10.4172/2470-1289.1000123
Vadivukkarasi S , Manikandan M Pavithra K and Vasudevan
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Minor Differences in the Proteome of Bacillus subtilis and Bacillus mojavensis Based upon High Abundance/ Conserved Protein Mass Spectra; Implications for Rapid, Improved Identification of Two Pathogen Genetically Closely Related
Review Article:  J Proteomics Enzymol
doi: 10.4172/2470-1289.1000119
Timothy Chambers , Renata Culak , Saheer E Gharbia and Haroun N Shah
Abstract  |   Full-text  |   PDF  |  
Ionic liquids, a Potential Solution for Cellulose Processing?
Editorial:  J Biocatal Biotransformation 2012, 1:1
doi: 10.4172/2324-9099.1000e102
Ye NI
Abstract  |   Full-text  |   PDF  |  
Purification, Immobilization, Stabilization and Characterization of Commercial Extract with β-galactosidase Activity
Research Article:  J Biocatal Biotransformation 2013, 2:1
doi: 10.4172/2324-9099.1000104
Chiara Calandri, Daniela P. Marques, Cesar Mateo, Alfonso V. Carrascosa, Jose M. Guisan, Gloria F. Lorente and Benevides C. Pessela
Abstract  |   Full-text  |   PDF  |  
Protocol for Direct Transformation through Gene Gun in Capsicum annuum L.Cv. Mathania
Research Article:  J Biocatal Biotransformation 2014, 3:1
doi: 10.4172/2324-9099.1000114
Rizwan M , Sharma R, Soni P and Singh G
Abstract  |   Full-text  |   PDF  |  
Enhancing Thermal Stability of Immobilized Raw Starch Digesting Amylase (RSDA)Using Different Additives
Research Article:  J Biocatal Biotransformation 2013, 2:2
doi: 10.4172/2324-9099.1000109
Onyetugo C Amadi, Bartho N Okolo, Cesar Mateo, Jose M Guisan and Benevides C Pessela
Abstract  |   Full-text  |   PDF  |  
Thioredoxin Catalysis and Inflammasome Regulation: Directions for Future Research
Editorial:  J Biocatal Biotransformation 2012, 1:2
doi: 10.4172/2324-9099.1000e107
Prasanna Tamarapu Parthasarathy, Phillips Oluwakemi and Narasaiah Kolliputi
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The Expression Pattern of the Acetoacetyl-CoA Synthetase and its Kinetic Parameters Facilitate the Use of Ketone Bodies in Liver during Feeding
Research Article:  J Proteomics Enzymol
doi: 10.4172/2470-1289.1000124
Francesca Aguilo, Nuria Camarero, Ana Luísa De Sousa- Coelho, Mar Gacias, Pedro F Marrero* and Diego Haro
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Enzyme Dynamics: Consensus and Controversy
Editorial:  J Biocatal Biotransformation 2012, 1:1
doi: 10.4172/2324-9099.1000e103
Amnon Kohen
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Xylanase Production from Aspergillus japonicus var aculeatus: Production using Agroindustrial Residues and Biobleaching Effect on Pulp
Research Article:  J Biocatal Biotransformation 2013, 2:1
doi: 10.4172/2324-9099.1000105
Guimarães NCA, Sorgatto M, Peixoto-Nogueira SC, Betini JHA, Zanoelo FF, Marques MR, Polizeli MLTM and Giannesi GC
Abstract  |   Full-text  |   PDF  |  
Naturally Decaying Agricultural Residues: Enriched Resources for Mining Novel Lignocellulolytic Enzymes
Review Article:  J Proteomics Enzymol
doi: 10.4172/2470-1289.1000120

Jemaneh Zeleke, Jasmina Nikodinovic-Runic and Evangelos Topakas

Abstract  |   Full-text  |   PDF  |  
Resuable Pectinase Nano Polymeric Particles
Research Article:  J Biocatal Biotransformation 2014, 3:1
doi: 10.4172/2324-9099.1000115
Ridvan Say, Ercan Cinar, Ozlem Bicen Unluer, Arzu Ersoz
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Bioconversion of R-(+)- Limonene to α-Terpineol in Emulsion Systems
Research Article:  J Biocatal Biotransformation 2014, 2:2
doi: 10.4172/2324-9099.1000110
Mirsasan Mirpour, Abdullah Kuang Dzulkefly and Fatemeh Alikhani
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Ring-Hydroxylating Dioxygenases: Biocatalysts with Remarkable Substrate Specificity and Exquisite Product Stereochemistry
Editorial:  J Biocatal Biotransformation 2012, 1:1
doi: 10.4172/2324-9099.1000e104
Christopher C. R. Allen
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The Frequency Analysis and the Atrial Fibrillation
Editorial:  J Biocatal Biotransformation 2012, 1:2
doi: 10.4172/2324-9099.1000e108
Wen-Chin Tsai and Yenn-Jiang Lin
Abstract  |   Full-text  |   PDF  |  
Immobilization of Haloalkane dehalogenase LinB from Sphingobium japonicum UT26 for Biotechnological Applications
Research Article:  J Biocatal Biotransformation 2013, 2:1
doi: 10.4172/2324-9099.1000106
Sarka Bidmanova, Jiri Damborsky and Zbynek Prokop
Abstract  |   Full-text  |   PDF  |  
Design of Experiments as Approach for Enhancing the Production of the Nicotinamide Co factor by Saccharomyces cervisiae
Research Article:  J Biocatal Biotransformation
doi: 10.4172/2324-9099.1000116
Najla Ben Akacha ,Rabaa Ben Asker and Mohamed Gargouri
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Cellulases and Xylanases Production by Penicillium Echinulatum in Submerged Cultivation: Statistical Optimization of Process Parameters
Research Article:  J Biocatal Biotransformation 2014, 2:2
doi: 10.4172/2324-9099.1000111
Carla Eliana Todero Ritter, Marli Camassola, Mauricio Moura da Silveira1 and Aldo José Pinheiro Dillon
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The Accuracy of Density Functional Theory Calculations in Biocatalysis
Review Article:  J Biocatal Biotransformation 2012, 1:1
doi: 10.4172/2324-9099.1000101
Sam P. de Visser
Abstract  |   Full-text  |   PDF  |  
Utilization of Self-Immobilized Eupenicillium katenegenes for Production of Methandienone
Research Article:  J Biocatal Biotransformation 2012, 1:2
doi: 10.4172/2324-9099.1000102
Ahmed EM
Abstract  |   Full-text  |   PDF  |  
Influence of Macromolecular Crowding on the Oxidation of ABTS by Hydrogen Peroxide Catalyzed by HRP
Research Article:  J Biocatal Biotransformation 2013, 2:1
doi: 10.4172/2324-9099.1000107
Laura Pitulice, Isabel Pastor, Eudald Vilaseca, Sergio Madurga, Adriana Isvoran, Marta Cascante and Francesc Mas
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