Dr. John Weber is an Associate Professor, Cross Appointment to Faculty of Medicine at Memorial University of Newfoundland, Canada. He earned his PhD in Pharmacology and Toxicology from the Medical College of Virginia.
His current research program has two major areas of focus. The first area is studying the mechanisms that contribute to altered physiology and pathology associated with the cerebellum, an area of the brain associated with fine motor coordination and motor learning. This line of studies includes behavioral analysis of ataxic mutant mouse models, and the effects of adolescent alcohol exposure on long-term motor function and cell physiology. In addition to behavioral analyses, we measure alterations in calcium signaling in various cells of the cerebellum using fluorescent imaging techniques in cerebellar slices derived from rats or mice. We also plan to conduct electrophysiology measurements in cerebellar cells primarily using the whole-cell patch-clamp technique. His second major area of research involves the study of agents that can protect the brain from traumatic insults and the aging process, particularly substances derived from natural products (e.g. species of berries native to Newfoundland and Labrador; oxyresveratrol). In this line of research I primarily utilize cell cultures from various brain regions and analyze biomarkers associated with neurodegenerative diseases as cells age, or after they are injured with in vitro models that produce mechanical strain, meant to mimic traumatic brain injury.