Biography
Professor Josep M. Argiles was born in Barcelona, Catalonia, Spain in 1956 and completed his undergraduate studies in Biology at the University of Barcelona graduating with a First Class Honours Degree and Special Prize for the best B.Sc. (1979). In 1981 he received his Doctorate in Biochemistry from the same university with Cum Laude obtaining the Prize for the best doctorate of that year. He then became Lecturer in Biochemistry and carried out postdoctoral work on acetone metabolism in mammals. In 1987 he undertook further postdoctoral training in the Laboratory of Metabolism and Molecular Biology at the National Institutes of Health, Bethesda, Maryland. In 1988 he went to the Metabolic Research Laboratory, Radcliffe Infirmary, Oxford, UK to work on the metabolic effects of cytokines. He later became Full Professor of Biochemistry and Molecular Biology of Cancer at the Faculty of Biology, University of Barcelona being the leader of a research group interested in cancer cachexia.His main contribution to the field of cancer research concern the mechanisms associated with cancer cachexia. Indeed, Prof. Argiles was the first scientist to describe the mechanism responsible for the increased protein breakdown in skeletal muscle of cancer patients which seems to be responsible for muscle wasting. He is responsible for the introduction of the concept of the cytokine balance of the cancer patient, the ratio of the pro-cachectic (TNF-a, IL-6, g-IFN..) to anti-cachectic (IL-10, sTNFRs….) cytokines. In addition to his work in describing mechanisms and mediators of cancer cachexia, Prof. Argiles has made interesting contributions in the form of pre-clinical studies regarding the pharmacological treatment of cachexia using different therapeutic strategies such as b2-agonists or anabolic cytokines, such as IL-15.
Research Interest
His main contribution to the field of cancer research concern the mechanisms associated with cancer cachexia. Indeed, Prof. Argiles was the first scientist to describe the mechanism responsible for the increased protein breakdown in skeletal muscle of cancer patients which seems to be responsible for muscle wasting. He is responsible for the introduction of the concept of the cytokine balance of the cancer patient, the ratio of the pro-cachectic (TNF-a, IL-6, g-IFN..) to anti-cachectic (IL-10, sTNFRs….) cytokines. In addition to his work in describing mechanisms and mediators of cancer cachexia, Prof. Argiles has made interesting contributions in the form of pre-clinical studies regarding the pharmacological treatment of cachexia using different therapeutic strategies such as b2-agonists or anabolic cytokines, such as IL-15.
Related Publications
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Teddy Rothstein
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Healthy Lifestyles in the Arab World: between Nutrition Economics and Food Politics
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Mixture of vegetable oils with balanced fatty acid Composition
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Ukwuru MU, Muritala A and Eze LU
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Methionine: The One Carbon Metabolic Cycle and its Relation to Pathogenesis
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Baha’a M Abu Salma*, Hamed R Takruri, Fawaz A Al Kazaleh, Fida M Thekrallah, Ali I Elmoumani and Kamil M Afram
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Leonard Rosenthall, Julian Falutz and Giovanni Guaraldi
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The Impact of Nutrition on Hashimoto Thyroiditis Patients: An Overview
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Nutritional Risk and Risk of Mucositis in Patients Treated with HDT Prior to Stem Cell Transplantation
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Vitamin D and Bone Health in Very Low and Extremely Low Birth Weight Infants
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The Potential Role of Î-Hydroxy-Î-Methylbutyrate in Preventing Muscle Loss in Chronic Diseases
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Dr. Daniel Mulder
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George V Dedoussis, Chara Vezou and Ioanna-Panagiota Kalafati
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Lack of Effect of Graded Doses of Vitamin D on Bone Metabolism of Breastfed Infants
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