Roshan Thapa, MD

Editorial Board Member

Assistant Professor,
Baruch S. Blumberg Institute,
Pennsylvania, USA

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He was interested in exploring molecular mechanisms of cell death activated by cytokines and viruses, and in therapeutic exploitation of these mechanisms for the treatment of human diseases. Recently, a new form of programmed cell death, necroptosis, has been described and being studied for its role in various disease pathogenesis. Understanding the pathways involved in necroptosis and finding novel regulatory molecules can become promising therapeutic avenue in infectious, inflammatory, and malignant diseases. He have focused his research interests in identifying molecules involved in interferon and viruses mediated cell death pathways. Recently, we have outlined the molecular mechanism of interferons- and influenza A virus-activated regulated cell death, and identified multiple key molecular targets involved.  We exploited one such target, NF-kappa B, to trigger interferons-mediated necroptosis in patient-derived refractory Renal Cell Carcinoma (RCC) cell lines. Currently, He is  working on the projects involved in therapeutic exploitation of regulated cell death in chronic hepatitis B infection and hepatocellular carcinoma.

Research Interest

Identifying molecules involved in interferon and viruses mediated cell death pathways, Exploring roles for NF-kappa B during antiviral innate immune responses, Outlining molecular mechanisms of programmed cell death during influenza A virus infection.

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